Novel Characterization of Sex Specific Biologic Signatures in Valvular Heart Disease

Description

This project aims to validate sex-specific biologic signatures associated with aortic valve disease developed in a large multicenter CMR registry, using unsupervised phenomapping. We aim to use advanced CMR techniques (MRF, DTI, chemical exchange transfer, and radiomics analysis) to determine advanced CMR predictors of reverse remodeling following aortic valve surgery and develop sex-specific thresholds for risk. Infrastructure developed by this study will enable development of an innovative, scalable, sex-specific precision medicine cardiovascular imaging pipeline to determine overall risk and treatment response.

Conditions

Aortic Regurgitation, Mitral Regurgitation, Aortic Stenosis

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Study Overview

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Study Details

Study overview

This project aims to validate sex-specific biologic signatures associated with aortic valve disease developed in a large multicenter CMR registry, using unsupervised phenomapping. We aim to use advanced CMR techniques (MRF, DTI, chemical exchange transfer, and radiomics analysis) to determine advanced CMR predictors of reverse remodeling following aortic valve surgery and develop sex-specific thresholds for risk. Infrastructure developed by this study will enable development of an innovative, scalable, sex-specific precision medicine cardiovascular imaging pipeline to determine overall risk and treatment response.

Novel Characterization of Sex Specific Biologic Signatures in Valvular Heart Disease

Novel Characterization of Sex Specific Biologic Signatures in Valvular Heart Disease

Condition
Aortic Regurgitation
Intervention / Treatment

-

Contacts and Locations

Cleveland

Cleveland Clinic, Cleveland, Ohio, United States, 44195

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 18-90 years of age
  • * Suspected moderate or severe (2-3+ or more) aortic regurgitation, or moderate or more aortic stenosis on the basis of prior known clinical history, echocardiogram or cardiac MRI.
  • * Acute traumatic cardiac injury
  • * Aortic dissection or aortic root rupture
  • * Congenital heart diseases such as patent ductus arteriosus, coarctation of aorta, ASD and VSD
  • * Presence of A-V fistula or intracardiac shunts
  • * Any contraindications to cardiac MRI including:
  • * Patients with any MR-incompatible implant, including cardiac pacemakers or defibrillators, or older types of cerebral aneurysm clips.
  • * Patients who weigh more than 440 lbs. or have a very wide waist circumference.
  • * Patients with claustrophobia may have difficulty tolerating the exam.

Ages Eligible for Study

18 Years to 90 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

The Cleveland Clinic,

Deborah Kwon, MD, PRINCIPAL_INVESTIGATOR, The Cleveland Clinic

Study Record Dates

2030-12-31