A Research Study to Look Into the Long-term Effect on Weight Loss of CagriSema in People With Obesity

Description

This study will look at how well CagriSema helps people with obesity lose weight compared to a "dummy medicine". CagriSema is a new medicine developed by Novo Nordisk. CagriSema cannot yet be prescribed by doctors. The study has two parts: First part is called the main phase and will last for 2 years, and second part is called the extension phase and will last for 1 year. In the main phase participants will either get CagriSema or "dummy medicine". Which treatment participants get is decided by chance and is not known by participants or the study doctor. In the extension phase participants will get either CagriSema or slowly reduce participants dose of CagriSema if participants had CagriSema in the main phase. Which treatment participants get is decided by chance and is not known by participants or the study doctor in both phases. If participants had "dummy medicine" in the main phase, participants will get CagriSema in the extension phase. Like all medicines, the study medicine may have side effects.

Conditions

Obesity

Study Overview

Study Details

Study overview

This study will look at how well CagriSema helps people with obesity lose weight compared to a "dummy medicine". CagriSema is a new medicine developed by Novo Nordisk. CagriSema cannot yet be prescribed by doctors. The study has two parts: First part is called the main phase and will last for 2 years, and second part is called the extension phase and will last for 1 year. In the main phase participants will either get CagriSema or "dummy medicine". Which treatment participants get is decided by chance and is not known by participants or the study doctor. In the extension phase participants will get either CagriSema or slowly reduce participants dose of CagriSema if participants had CagriSema in the main phase. Which treatment participants get is decided by chance and is not known by participants or the study doctor in both phases. If participants had "dummy medicine" in the main phase, participants will get CagriSema in the extension phase. Like all medicines, the study medicine may have side effects.

Long-term Efficacy and Safety of Cagrilintide s.c. 2.4 mg in Combination With Semaglutide s.c. 2.4 mg (CagriSema 2.4 mg/2.4 mg) Once Weekly Versus Placebo in Participants With Obesity

A Research Study to Look Into the Long-term Effect on Weight Loss of CagriSema in People With Obesity

Condition
Obesity
Intervention / Treatment

-

Contacts and Locations

Covina

Valley Clinical Trials, Covina, California, United States, 91723

Walnut Creek

Diablo Clinical Research, Inc., Walnut Creek, California, United States, 94598

New Haven

Yale University School Of Medicine, New Haven, Connecticut, United States, 06519

Honolulu

East West Medical Research Institute_Honolulu, Honolulu, Hawaii, United States, 96814

Louisville

L-MARC Research Center, Louisville, Kentucky, United States, 40213

Saint Peters

StudyMetrix Research LLC, Saint Peters, Missouri, United States, 63303

Spartanburg

Spartanburg Medical Research, Spartanburg, South Carolina, United States, 29303

Bristol

Holston Medical Group_Bristol, Bristol, Tennessee, United States, 37620

Dallas

North Texas Endocrine Center, Dallas, Texas, United States, 75231

Arlington

Washington Cntr Weight Mgmt, Arlington, Virginia, United States, 22206

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Male or female.
  • * Age above or equal to 18 years at the time of signing informed consent.
  • * Body mass index (BMI) greater than or equal to (\>=) 35.0 kilograms per meter square (kg/m\^2).
  • * Glycated haemoglobin (HbA1c) \>= 6.5 percent (48 millimoles per mole \[mmol/mol\]) as measured by the central laboratory at screening.
  • * History of type 1 or type 2 diabetes.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Novo Nordisk A/S,

Clinical Transparency (dept. 2834), STUDY_DIRECTOR, Novo Nordisk A/S

Study Record Dates

2028-11-17