Creation of a Prospective Data Collecting Registry for Genicular Artery Embolization for Arthritis

Description

The goal of this study is to create a prospective registry (\<100 patients) to show the effectiveness of the genicular artery embolization procedure overtime in reducing bilateral or unilateral osteoarthritic knee pain as measured by Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score.

Conditions

Knee Osteoarthritis, Knee Osteoarthritis (Knee OA), Knee Osteoarthritis (OA)

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Study Overview

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Study Details

Study overview

The goal of this study is to create a prospective registry (\<100 patients) to show the effectiveness of the genicular artery embolization procedure overtime in reducing bilateral or unilateral osteoarthritic knee pain as measured by Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score.

Creation of a Prospective Data Collecting Registry for Genicular Artery Embolization for Arthritis (GAE)

Creation of a Prospective Data Collecting Registry for Genicular Artery Embolization for Arthritis

Condition
Knee Osteoarthritis
Intervention / Treatment

-

Contacts and Locations

Chicago

University of Chicago Duchossois Center for Advanced Medicine, Chicago, Illinois, United States, 60637

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Patients aged \>=18
  • * Bilateral or unilateral knee pain attributed to knee osteoarthritis (KOA). For bilateral KOA patients, the more severe knee will be permitted inclusion to the registry
  • * Grade 1-3 Osteoarthritis as diagnosed on standing weight-bearing knee radiographs per the Kellen-Lawrence Grading scale
  • * Knee pain \>6 months refractory to conservative medical management (Nonsteroidal anti-inflammatory drugs, acetaminophen, etc.)
  • * Not eligible for surgical knee replacement or patient's personal preference to undergo Genicular Artery Embolization (GAE) for reasons such as minimally invasiveness of GAE
  • * Active malignancy
  • * Active infection of the affected knee
  • * Platelets \<50,000/uL, INR \>2.0 (unless on anticoagulation that can be reversed or performing radial/pedal access without reversal)
  • * Corticosteroid injection of the affected knee within 3 months of enrollment
  • * Rheumatoid arthritis or other seronegative arthropathy
  • * Previous surgery (excluding arthroscopy) of the affected knee
  • * Grade 4 per Kellgren-Lawrence Grading Scale of the affected knee
  • * Pregnancy or expected pregnancy
  • * Glomerular Filtration Rate (GFR) \<30
  • * Anaphylactic reaction to iodinated contrast
  • * Moderate to severe pain in other lower limb joints
  • * Body weight \>400 lbs. (prohibiting safe angiography)
  • * Peripheral arterial disease of the treated extremity (Rutherford Grade 2 or greater)

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Chicago,

Study Record Dates

2028-10-01