Stress and Pain in People Living With HIV

Description

This is a basic human experimental study utilizing 4 groups of individuals with and without HIV and complex morbidities of cannabis use disorder and major depression who will participate in 2 sessions of the Yale Pain Stress Task (YPST) and follow-up phase to assess drug use and mood symptoms.

Conditions

HIV, Depression, Cannabis Use Disorder, Stress, Pain

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Study Overview

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Study Details

Study overview

This is a basic human experimental study utilizing 4 groups of individuals with and without HIV and complex morbidities of cannabis use disorder and major depression who will participate in 2 sessions of the Yale Pain Stress Task (YPST) and follow-up phase to assess drug use and mood symptoms.

Stress-immune Mechanisms for People Living With HIV, CUD and Depression

Stress and Pain in People Living With HIV

Condition
HIV
Intervention / Treatment

-

Contacts and Locations

New Haven

The Yale Stress Center, New Haven, Connecticut, United States, 06519

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * good health as verified by screening examination
  • * Able to read English and complete study evaluations and provide informed written and verbal consent. Additional criteria PLWH
  • * HIV-1 lab test positive
  • * undetectable viral load
  • * good ART adherence
  • * CB positive urine toxicology
  • * meet DSM-5 criteria for CUD and MDD as assessed using SCID-I. HC
  • * HIV-1 test negative
  • * urine toxicology negative
  • * no major medical and psychiatric diagnoses based on DSM-V.
  • * HIV-1 test positive
  • * urine toxicology negative
  • * no major medical and psychiatric diagnoses based on DSM-V.
  • * HIV-1 test negative
  • * urine toxicology positive
  • * meet DSM-5 criteria for CUD and MDD as assessed using SCID-I
  • * meet primary, current moderate and severe criteria for other SUD including cocaine, alcohol, opiates, sedatives, nicotine
  • * current use or past history of cocaine or opioid use disorder
  • * history of any psychotic disorder
  • * current diagnoses of bipolar disorder and PTSD
  • * psychotic or otherwise severely psychiatrically disabled (i.e., suicidal, homicidal, current mania)
  • * significant underlying medical conditions such as cerebral, renal, thyroid or cardiac pathology that would interfere with study participation
  • * medications with known central effects on HPA axis and cytokines/immune function
  • * women who are pregnant, nursing or those using hormonal birth control that affect HPA axis cortisol responses.

Ages Eligible for Study

18 Years to 68 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Yale University,

Rajita Sinha, Ph.D., PRINCIPAL_INVESTIGATOR, Yale University

Study Record Dates

2030-01-31