RECRUITING

Breathing Practice for Brain and Mental Health in Cancer and Neurodegenerative Diseases

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Conditions

Malignant Brain NeoplasmMalignant Solid NeoplasmMultiple SclerosisNeuroendocrine TumorProstate Carcinoma

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This clinical trial studies the effect of respiratory training for enhancing brain and mental health among patients with multiple sclerosis (MS) and cancer (along with their caregivers). The relationship between respiration, cardiovascular effects in the brain, mental health, and neurophysiological mechanisms are significant for patient populations facing complex health challenges, such as those with cancer and neurodegenerative disease, and their caregivers. By measuring oxygen delivery to brain tissues and cerebrospinal fluid flow, this trial may help researchers investigate the potential benefits of respiratory training for patients with MS and cancer and their caregivers.

Official Title

Enhancing Brain and Mental Health Through Respiratory Training: Clinical Applications in Cancer and Neurodegenerative Disease Care for Patients and Caregivers (Breathing Study)

Quick Facts

Study Start:2025-02-16
Study Completion:2027-01-18
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06788886

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 85 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * STUDY 1: Participants must be physically fit enough to perform light exercise.
  2. * STUDY 1: Should read and understand English well enough to consent, complete measures, and follow instructions.
  3. * STUDY 1: Must have access to a smartphone or tablet.
  4. * STUDY 2: Participants must be physically fit enough to perform light exercise.
  5. * STUDY 2: Cancer patients may have prostate cancer, neuroendocrine tumor, or brain cancer in any stage.
  6. * STUDY 2: The main focus is on pairs of cancer patients and their respective caregivers, but individual cancer patients or individual caregivers are also acceptable.
  7. * STUDY 2: Participants should read and understand English well enough to consent, complete measures, and follow instructions.
  8. * STUDY 2: They also must have access to a smartphone or tablet.
  9. * STUDY 3: Participants must be physically fit enough to perform light exercise.
  10. * STUDY 3: The patient should have multiple sclerosis.
  11. * STUDY 3: Participants should read and understand English well enough to consent, complete measures, and follow instructions.
  12. * STUDY 3: They also must have access to a smartphone or tablet.
  1. * STUDY 1: Participants incompatible with MRI machines due to factors such as pacemakers or metallic implants.
  2. * STUDY 1: Additionally, those with chronic medical conditions, including heart disease (coronary artery disease, congestive heart failure, hypertension, cardiac arrhythmia), chronic obstructive pulmonary disease (COPD), cystic fibrosis, cancer, diabetes, sleep apnea, aneurysms, and neurological conditions (epilepsy, Alzheimer's disease, Huntington' disease, essential tremor and Parkinson disease) are excluded.
  3. * STUDY 1: Participants with psychiatric conditions such as psychosis, suicidality, bipolar disorder, major depression, and substance use disorders are excluded.
  4. * STUDY 1: Participants serving as caregivers for any of the aforementioned conditions and for other illnesses such as cancer or neurological disorders, are also excluded.
  5. * STUDY 1: Further exclusions apply to those with severe vision, hearing impairments, have a body mass index (BMI) over 30, and those who are pregnant.
  6. * STUDY 1: Those planning to become pregnant during the study period will be excluded.
  7. * STUDY 2: Participants incompatible with MRI machines due to factors such as pacemakers or metallic implants are excluded, as are those with chronic lung disease (chronic obstructive pulmonary disease \[COPD\], cystic fibrosis), aneurysms, and those who are pregnant.
  8. * STUDY 2: Those planning to become pregnant during the study period will be excluded.
  9. * STUDY 3: Participants incompatible with MRI machines due to factors such as pacemakers or metallic implants are excluded, as are those with chronic lung disease (chronic obstructive pulmonary disease \[COPD\], cystic fibrosis), aneurysms, and those who are pregnant.
  10. * STUDY 3: Those planning to become pregnant during the study period will be excluded.

Contacts and Locations

Study Contact

Clinical Trials Referral Office
CONTACT
855-776-0015
mayocliniccancerstudies@mayo.edu

Principal Investigator

Paul H. Min, PhD
PRINCIPAL_INVESTIGATOR
Mayo Clinic in Rochester

Study Locations (Sites)

Mayo Clinic in Rochester
Rochester, Minnesota, 55905
United States

Collaborators and Investigators

Sponsor: Mayo Clinic

  • Paul H. Min, PhD, PRINCIPAL_INVESTIGATOR, Mayo Clinic in Rochester

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-02-16
Study Completion Date2027-01-18

Study Record Updates

Study Start Date2025-02-16
Study Completion Date2027-01-18

Terms related to this study

Additional Relevant MeSH Terms

  • Malignant Brain Neoplasm
  • Malignant Solid Neoplasm
  • Multiple Sclerosis
  • Neuroendocrine Tumor
  • Prostate Carcinoma