Exercise Physiology in Patients With Aortic Aneurysm and Its Correlation With Mechanical Properties of Aortic Tissue

Description

Aortic aneurysm patients benefit from exercise yet patients and physicians do not know a safe level. Cardiac MRI (CMR) is the most comprehensive imaging modality for phenotypic evaluation of patients with cardiac disease but it has not been used to study aneurysm patients. The purpose of this project is use exercise CMR to understand regional aortic function and quantify aortic elasticity in these populations while exercising. This project will correlate the exercise CMR data with the biomechanical properties of the patient's aortic tissue, including epiaortic ultrasound and TEE performed during aortic repair, and explanted aortic specimens subjected to ex vivo uniaxial tensile testing. Correlating this data with aortic response to exercise will allow us to understand how aortic size, in vivo circumferential strain values, ex vivo aortic efficiency and mechanical failure all relate to exercise physiology.

Conditions

Aortic Aneurysm

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Study Overview

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Study Details

Study overview

Aortic aneurysm patients benefit from exercise yet patients and physicians do not know a safe level. Cardiac MRI (CMR) is the most comprehensive imaging modality for phenotypic evaluation of patients with cardiac disease but it has not been used to study aneurysm patients. The purpose of this project is use exercise CMR to understand regional aortic function and quantify aortic elasticity in these populations while exercising. This project will correlate the exercise CMR data with the biomechanical properties of the patient's aortic tissue, including epiaortic ultrasound and TEE performed during aortic repair, and explanted aortic specimens subjected to ex vivo uniaxial tensile testing. Correlating this data with aortic response to exercise will allow us to understand how aortic size, in vivo circumferential strain values, ex vivo aortic efficiency and mechanical failure all relate to exercise physiology.

Exercise Physiology in Patients With Aortic Aneurysm and Its Correlation With Mechanical Properties of Aortic Tissue

Exercise Physiology in Patients With Aortic Aneurysm and Its Correlation With Mechanical Properties of Aortic Tissue

Condition
Aortic Aneurysm
Intervention / Treatment

-

Contacts and Locations

Cleveland

Cleveland Clinic, Cleveland, Ohio, United States, 44195

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Healthy controls for baseline comparison
  • 1. Must be 18 years or older
  • 2. No history of cardiovascular disease, neither hypertension, diabetes nor hypercholesterolemia
  • 2. Aneurysm patients who have not yet been operated on but are currently being monitored
  • 1. Must be 18 years or older
  • 2. No history of operation for aortic aneurysm
  • 3. Pre-operative aneurysm patients: imaged pre-operatively and 12 months
  • 1. Patients admitted at the CCF cardiothoracic services for elective surgery due to aortic aneurysms
  • 2. Must be 18 years or older
  • * Contra-indication for MRI
  • * Heart pacemaker/defibrillator.
  • * Electronic/implanted stimulators or devices, including deep brain stimulator, vagus nerve stimulator, bladder stimulator, spine stimulator, neurostimulators; implanted electrodes or wires.
  • * Cochlear implant or other ear implants.
  • * Implanted drug pumps (insulin, narcotic/pain medications, drugs to treat spasticity).
  • * Programmable shunt.
  • * Aneurysm clips and coils.
  • * Stents (not located in heart).
  • * Filters (for example, blood clot filters).
  • * Metal fragment in your body or eye (eg, BBs, bullets, shrapnel, metal pieces or shavings).
  • * Congenital heart diseases such as patent ductus arteriosus, coarctation of aorta, ASD and VSD
  • * Presence of A-V fistula or intracardiac shunts
  • * Moderate or severe dysfunction in multiple valves
  • * Patients with significant claustrophobia
  • * Patients unable to pedal a supine bicycle
  • * Those who require supplemental oxygen

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

The Cleveland Clinic,

Deborah Kwon, MD, PRINCIPAL_INVESTIGATOR, The Cleveland Clinic

Study Record Dates

2029-03-31