Sildenafil to Prevent and Reduce Cancer Related Cognitive Impairment

Description

This study is examining the effects of standard of care cancer treatment as well as a medication called Sildenafil, on the cancer associated fatigue, cognition and the gut microbiome.

Conditions

Cancer

Talk to us

Study Overview

On this page

Study Details

Study overview

This study is examining the effects of standard of care cancer treatment as well as a medication called Sildenafil, on the cancer associated fatigue, cognition and the gut microbiome.

Sildenafil to Prevent and Reduce Cancer Related Cognitive Impairment

Sildenafil to Prevent and Reduce Cancer Related Cognitive Impairment

Condition
Cancer
Intervention / Treatment

-

Contacts and Locations

Galveston

The University of Texas Medical Branch, Galveston, Texas, United States, 77555

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Female
  • * Ages 30 - 50 years
  • * Self-reported menses occurrence within past 12 months
  • * Diagnosis of ER+/HER2- breast cancer
  • * Willing and able to comply with study procedures
  • * Willing and able to provide consent
  • * Untreated thyroid disorder
  • * Untreated diabetes
  • * BMI \>30
  • * Current treatment with metformin
  • * Diagnosed neuromuscular disease
  • * Diagnosed neurovascular disease
  • * Prior history of cognitive impairment
  • * Prior history of chemotherapy treatment
  • * HIV, Hepatitis B or Hepatitis C
  • * Systolic blood pressure \<90 or \>170, diastolic blood pressure \<50 or \>110 after repeated evaluation with proper cuff. This range is the acceptable range stated in the prescribing information for sildenafil (\>90/50 and \<170/110)
  • * Use of alpha blockers in the past 2 weeks
  • * Use of PDE5 inhibitors in the past 2 weeks
  • * Use of nitrates
  • * Subjects with MRI incompatible devices
  • * Subjects with severe claustrophobia
  • * Any medical condition that, in the opinion of the investigator, would place the subject at increased risk for participation

Ages Eligible for Study

30 Years to 50 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

The University of Texas Medical Branch, Galveston,

Melinda Sheffield-Moore, PhD, PRINCIPAL_INVESTIGATOR, University of Texas

Study Record Dates

2030-06-01