RECRUITING

Pain Reprocessing Therapy in Post-Operative Knee Pain

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Conditions

Pain, ChronicKnee Pain Chronicchronic painPain Reprocessing Therapyknee paintotal knee replacementTotal Knee Arthroplastymind-bodymindfulnessTKAPRT

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical trial is to learn whether Pain Reprocessing Therapy (PRT) can help adults with knee pain after knee replacement surgery. The study is comparing PRT to usual care (the regular treatment people get after surgery) to see which works better for relieving pain. The main questions the study aims to answer are: 1. Does PRT help lower pain in people who have chronic knee pain after knee surgery? 2. How do the effects of PRT compare with usual care in terms of pain relief and other factors such as anxiety, depression, and sleep? 3. How does PRT impact the brain? Participants will: 1. Be randomly assigned to receive either PRT or usual care. 2. Complete questionnaires about their pain and health. 3. If in the PRT group, have eight weekly therapy sessions over video calls with a therapist. 4. If interested, may also take part in an optional EEG test to measure brain activity related to pain.

Official Title

Pain Reprocessing Therapy in Post-Operative Knee Pain

Quick Facts

Study Start:2025-06-01
Study Completion:2026-09-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06800209

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Patients are deemed eligible at 3 months post-operatively if: The patient completed a primary knee replacement \[surgery completed without complication and patient exhibits full mechanical joint function, as determined by the treating physician (good range of motion, stability, and wound healing; absence of swelling)\] and patient reports last week average knee pain ≥ 4 of 10 on Numeric Rating Scale (NRS).
  2. * Reported pre-operative chronic knee pain of at least 6 months duration prior to surgery
  3. * The procedure was a primary (not a revision) knee replacement
  4. * Proficient in English
  1. * Patients who are not willing to participate in a telehealth visit.
  2. * Patients with pre-op chronic pain but who do not have post-operative pain after the three month time period.
  3. * Major surgery for lower extremity or spine within 1 year of the current primary TKA.
  4. * Active suicidal ideation with intent, recent history of suicide attempt, or self-harm behaviors within the past 5 years (including non-suicidal self-harm).
  5. * Recent history of inpatient psychiatric hospitalization within the past 5 years.
  6. * Active, current psychosis or mania.
  7. * Active, current substance abuse, or problems with substance abuse within the past 2 years.
  8. * Instability in living conditions or major interfering life events:
  9. * Major surgery or other major medical event planned in coming 6 months.
  10. * Uncertain whether they will have suitable conditions for telehealth appointments over the next 2 months, including access to a computer or tablet, reliable high-speed internet, and a quiet, comfortable room that is consistently available.
  11. * Major, interfering changes in employment or housing anticipated over the next 6 months.
  12. * Neurological conditions (e.g., Alzheimer's, dementia, mild cognitive impairment, Huntington's disease, multiple sclerosis, cerebral palsy). This will be case-by-case decision made by PI to determine if the condition may interfere with treatment and warrant exclusion.
  13. * Self-reported diagnosis of an autoimmune disease (e.g., rheumatoid arthritis, polymyalgia rheumatica, scleroderma, lupus, polymyositis, or another autoimmune disorder).
  14. * Currently or plan to be involved in lawsuits related to pain in next 6 months, currently or plan to apply for any disability payments related to the pain in next 6 months, or received legal settlement or other disability payments related to the pain over past 2 years.
  15. * Are unable or uncomfortable with completing a dry cap EEG.
  16. * Has had a history of abnormal EEGs.

Contacts and Locations

Study Contact

Allina Nocon, PhD
CONTACT
212-774-2572
Complexjoint@hss.edu

Study Locations (Sites)

University of Colorado Anschutz Medical Campus
Aurora, Colorado, 80045
United States
Hospital for Special Surgery
New York, New York, 10021
United States

Collaborators and Investigators

Sponsor: University of Colorado, Denver

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-06-01
Study Completion Date2026-09-30

Study Record Updates

Study Start Date2025-06-01
Study Completion Date2026-09-30

Terms related to this study

Keywords Provided by Researchers

  • chronic pain
  • Pain Reprocessing Therapy
  • knee pain
  • total knee replacement
  • Total Knee Arthroplasty
  • mind-body
  • mindfulness
  • TKA
  • PRT

Additional Relevant MeSH Terms

  • Pain, Chronic
  • Knee Pain Chronic