Opioid Use Disorder and Pain

Description

The goal of this observational study is to characterize the brain processes of pain avoidance learning dysfunctions in individuals with opioid use disorder (OUD). The main questions it aims to answer are: Compared with healthy controls, do those with OUD exhibit impaired avoidance learning in response to pain? What are the brain processes that are associated with this avoidance learning dysfunction? Do these brain processes serve to predict future use or relapse? Researchers will compare those with OUD and healthy controls to determine avoidance learning dysfunction and its relationship with opioid use. Participants will be performing a learning task inside an fMRI scanner. Those with OUD will also be followed up for a year to determine future opioid use.

Conditions

Opioid Use Disorder, Healthy Controls Group - Age and Sex-matched

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Study Overview

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Study Details

Study overview

The goal of this observational study is to characterize the brain processes of pain avoidance learning dysfunctions in individuals with opioid use disorder (OUD). The main questions it aims to answer are: Compared with healthy controls, do those with OUD exhibit impaired avoidance learning in response to pain? What are the brain processes that are associated with this avoidance learning dysfunction? Do these brain processes serve to predict future use or relapse? Researchers will compare those with OUD and healthy controls to determine avoidance learning dysfunction and its relationship with opioid use. Participants will be performing a learning task inside an fMRI scanner. Those with OUD will also be followed up for a year to determine future opioid use.

Opioid Use Disorder and Pain

Opioid Use Disorder and Pain

Condition
Opioid Use Disorder
Intervention / Treatment

-

Contacts and Locations

New Haven

Connecticut Mental Health Center, S105, New Haven, Connecticut, United States, 06519

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Any significant current medical condition such as neurological, cardiovascular, endocrine, renal, hepatic, thyroid pathology.
  • 2. History of head injury with loss of consciousness (\> 30 minutes).
  • 3. Current or past DSM-IV or DSM 5 diagnosis of a major psychiatric disorder (other than opioid and nicotine use disorders) that required hospitalization, or that required daily medications for over 4 weeks. Such medications include antidepressants, anticholinergics, antipsychotics, anxiolytics, lithium, psychotropic drugs not otherwise specified including herbal products, drugs with psychomotor effects or with anxiolytics, stimulant, or antipsychotic properties, any other psychoactive drugs, and sedatives/hypnotics. Individuals with current depressive or anxiety symptoms requiring treatment or currently being treated for these symptoms will be excluded.
  • 4. Any subjects with foreign ferromagnetic metal objects in their body or other MR contraindications will be excluded. Individuals who previously worked in metal industry or with metal shavings (due to a risk of any remaining metal particles moving in the eye during the MRI).
  • 5. Pregnant or lactating women will not be recruited for the study.
  • 6. Cannot or are not willing to lie comfortably flat on his/her back for up to 2 hours in the MRI scanner (self-report).
  • 7. Body weight \> 550 lbs. The MR scanner bed is tested to a weight limit of 550 lbs.
  • 8. No pPlans to relocate out of state in the next 12 months (for follow-up purposes).
  • 9. Still experiencing significant withdrawal symptoms.
  • 1. Between ages 21-60 years old.
  • 2. Able to read and write and provide written informed consent.
  • 3. Use non-prescribed opioids on a weekly basis or more.
  • 4. Physically healthy with no major medical illnesses, history of head injury or any neurological illness
  • 5. No plans to relocate out of state in the next 12 months (for follow-up purposes).
  • 6. Speak English

Ages Eligible for Study

21 Years to 60 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Yale University,

Thang M Le, PhD, PRINCIPAL_INVESTIGATOR, Yale University

Study Record Dates

2028-01