Smart Underwear to Measure Diet-Induced Hydrogen Sulfide Production

Description

The purpose of this study is to evaluate the ability of a wearable Smart Underwear prototype device to quantify diet-induced changes in gut microbial hydrogen sulfide (H₂S) production. The core design is a single-site, 2-period, crossover feeding study with 6-day diet periods and an approximately 11-day washout period. Participants are fed each of two isocaloric diets designed to contrast gut microbial H₂S production (i.e., a high cysteine vs. low cysteine diet), in a random order.

Conditions

Hydrogen Sulfide, Gastrointestinal Microbiome

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Study Overview

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Study Details

Study overview

The purpose of this study is to evaluate the ability of a wearable Smart Underwear prototype device to quantify diet-induced changes in gut microbial hydrogen sulfide (H₂S) production. The core design is a single-site, 2-period, crossover feeding study with 6-day diet periods and an approximately 11-day washout period. Participants are fed each of two isocaloric diets designed to contrast gut microbial H₂S production (i.e., a high cysteine vs. low cysteine diet), in a random order.

Employing Smart Underwear to Measure Gut Microbial Hydrogen Sulfide Production

Smart Underwear to Measure Diet-Induced Hydrogen Sulfide Production

Condition
Hydrogen Sulfide
Intervention / Treatment

-

Contacts and Locations

Aurora

University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States, 80045

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Generally healthy volunteers defined as having no major known health conditions (e.g., diabetes, cancer, hypertension, etc.).
  • * Normal bowel movements, with approximately 1 bowel movement reported per day
  • * Willing to discuss flatus
  • * Ages \>18yrs
  • * Willing to complete the entire study protocol, i.e. eating all of the food that is provided and completing all required measurements.
  • * Self-report or other evidence of diabetes, other endocrine/metabolic abnormality, dyslipidemia, morbid obesity, severe hypertension, chronic kidney disease, liver disease, pulmonary disease, gastrointestinal, and cardiovascular diseases
  • * Chronic medications for any of the above conditions
  • * Food allergy that interferes with ability to complete the study
  • * Food preferences, intolerance, or dietary requirements that would interfere with diet adherence
  • * Planned dietary changes during the study period
  • * Lack of appropriate food refrigeration and preparation equipment (e.g.- oven or microwave)
  • * Pregnancy or planned pregnancy in the next month
  • * Physical measurements: BMI \> 35 kg/m2

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Colorado, Denver,

Noel T Mueller, PhD, PRINCIPAL_INVESTIGATOR, University of Colorado, Denver

Andrew B Hall, PhD, PRINCIPAL_INVESTIGATOR, University of Maryland, College Park

Study Record Dates

2027-06-30