Non-invasive Vagus Nerve Stimulation (nVNS) and Cognition in Young Adult Vapers - A Pilot Study

Description

The purpose of this study is to assess the effects of non-invasive vagus nerve stimulation (nNVS) on cognitive functioning in the users of e-cigarettes or vaping products. The investigators will use a digital wellness companion product (TRUVAGA™ device) that provides mild transcutaneous nVNS. The participants will be randomized to receive either a 2-min nNVS stimulation or control stimulation in the neck region followed by completion of two cognitive tests of attention.

Conditions

Vaping

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Study Overview

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Study Details

Study overview

The purpose of this study is to assess the effects of non-invasive vagus nerve stimulation (nNVS) on cognitive functioning in the users of e-cigarettes or vaping products. The investigators will use a digital wellness companion product (TRUVAGA™ device) that provides mild transcutaneous nVNS. The participants will be randomized to receive either a 2-min nNVS stimulation or control stimulation in the neck region followed by completion of two cognitive tests of attention.

Vaping and Vagal Neuromodulation of Cognition

Non-invasive Vagus Nerve Stimulation (nVNS) and Cognition in Young Adult Vapers - A Pilot Study

Condition
Vaping
Intervention / Treatment

-

Contacts and Locations

Philadelphia

Temple University, Philadelphia, Pennsylvania, United States, 19122

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Healthy young adults
  • * Age range 18-25 years
  • * Current or prior users of e-cigarettes
  • * Have any rash, infection, swelling, cut, soreness, drug patch, surgical scar on the neck area
  • * Have any implantable medical device in their body such as a pacemaker, hearing aid implant, or any other metallic/electronic device
  • * Have any hearing or vision problems that are not corrected
  • * Are pregnant or breastfeeding
  • * Have any learning disabilities
  • * Have a medical history of any of the following condition
  • * Meningitis
  • * Traumatic brain injury
  • * Seizure
  • * Syncope
  • * Schizophrenia
  • * Schizoaffective disorder
  • * Bulimia (eating disorder)
  • * Other serious neurological illness
  • * Have a medical history of any of the following cardiac disorder
  • * Carotid atherosclerosis or carotid artery disease
  • * Cervical vagotomy
  • * First degree atrioventricular block or prolonged QT interval
  • * Are taking any medications for to treat hypertension, arrhythmias, or are on calcium channel blockers

Ages Eligible for Study

18 Years to 25 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Temple University,

Vinay Parikh, PhD, PRINCIPAL_INVESTIGATOR, Temple University

Jason Chein, PhD, PRINCIPAL_INVESTIGATOR, Temple University

Tania Giovannetti, PhD, PRINCIPAL_INVESTIGATOR, Temple University

Study Record Dates

2028-02-09