RECRUITING

A Study to Measure the Effects of Using Tradipitant on Nausea and Vomiting After GLP-1R Agonist Use

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this study is to measure the effects of using Tradipitant after GLP-1R agonist use on nausea and vomiting in healthy overweight, class I, or class II obese volunteers. The study is placebo-controlled with two treatment arms.

Official Title

A Proof of Concept, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effects of Tradipitant on Nausea and Vomiting After GLP-1R Agonist Administration in Healthy Overweight Class I or Class II Obese Volunteers

Quick Facts

Study Start:2025-02-25
Study Completion:2025-07-06
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06804603

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Body Mass Index 25-40 kg/m\^2 inclusive
  2. * No serious medical problems or chronic diseases, specifically no type I or type II diabetes
  1. * Another disorder that contributes to gastrointestinal symptoms
  2. * History of intolerance and/or hypersensitivity to NK-1 receptor antagonists
  3. * History of intolerance and/or hypersensitivity to GLP-1 receptor agonists
  4. * Exposure to any investigational medication within the past 60 days

Contacts and Locations

Study Contact

Vanda Pharmaceuticals
CONTACT
(202) 734-3400
clinicaltrials@vandapharma.com

Principal Investigator

Vanda Pharmaceuticals
STUDY_DIRECTOR
Vanda Pharmaceuticals

Study Locations (Sites)

Vanda Investigational Site
Los Angeles, California, 90025
United States
Vanda Investigational Site
Rochester, Minnesota, 55905
United States

Collaborators and Investigators

Sponsor: Vanda Pharmaceuticals

  • Vanda Pharmaceuticals, STUDY_DIRECTOR, Vanda Pharmaceuticals

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-02-25
Study Completion Date2025-07-06

Study Record Updates

Study Start Date2025-02-25
Study Completion Date2025-07-06

Terms related to this study

Keywords Provided by Researchers

  • GLP-1R agonist
  • semaglutide
  • obesity
  • nausea
  • vomiting

Additional Relevant MeSH Terms

  • Obesity