RECRUITING

Urine Methylation Markers in UTUC

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This is a research study to measure DNA markers in the urine of patients with upper tract urothelial cancer (UTUC) before surgery and during follow-up visits. Identifying these DNA markers could improve diagnosis before surgery, help assess risk, and predict early recurrence of the cancer. Urine samples will be de-identified and sent to Pangea Laboratory LLC for analysis. The results of this test will be compared to the traditional tests in upper tract urothelial cancer, such as cells in the urine and tissue biopsy.

Official Title

Urine-based Methylation Markers in the Diagnosis and Surveillance of Upper Tract Urothelial Carcinoma

Quick Facts

Study Start:2025-05-07
Study Completion:2026-06
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06805630

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * \>=18 years
  2. * Primary UTUC
  1. * Patients who do not understand and/or are unwilling to sign a written informed consent

Contacts and Locations

Study Contact

Alireza Ghoreifinejadian, M.D.
CONTACT
919-684-8111
alireza.ghoreifi@duke.edu

Principal Investigator

Michael Abern, MD
PRINCIPAL_INVESTIGATOR
Duke University

Study Locations (Sites)

Duke University
Durham, North Carolina, 27710
United States

Collaborators and Investigators

Sponsor: Duke University

  • Michael Abern, MD, PRINCIPAL_INVESTIGATOR, Duke University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-05-07
Study Completion Date2026-06

Study Record Updates

Study Start Date2025-05-07
Study Completion Date2026-06

Terms related to this study

Keywords Provided by Researchers

  • UTUC

Additional Relevant MeSH Terms

  • Upper Tract Urothelial Cancer