Project neuroARTEMIS

Description

The purpose of this research is to understand how chronic stress affects the way our brain and immune systems function, and in turn how this affects the way people feel, think, and behave. By learning more about how these processes work, the hope is to be able to develop better treatments to help with problems like depression and substance use. This study is intended for individuals that are HIV positive, currently taking prescription antiretroviral medications, and use stimulants. Through this intervention, the aim is to determine if this positive affect intervention can lead to reductions in stimulant use and depressed mood.

Conditions

Stimulant Use, Human Immunodeficiency Virus (HIV), Depression

Study Overview

Study Details

Study overview

The purpose of this research is to understand how chronic stress affects the way our brain and immune systems function, and in turn how this affects the way people feel, think, and behave. By learning more about how these processes work, the hope is to be able to develop better treatments to help with problems like depression and substance use. This study is intended for individuals that are HIV positive, currently taking prescription antiretroviral medications, and use stimulants. Through this intervention, the aim is to determine if this positive affect intervention can lead to reductions in stimulant use and depressed mood.

Project ARTEMIS: A Mechanistic Clinical Trial of Neuroimmune Pathways.

Project neuroARTEMIS

Condition
Stimulant Use
Intervention / Treatment

-

Contacts and Locations

Winston-Salem

Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States, 27101

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 18-59 years old
  • * Weekly use of stimulants reported in the past month or a score of 4 or more on the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST)
  • * Confirmed HIV diagnosis
  • * Current receipt of daily oral antiretroviral therapy (ART) medication
  • * English fluency/literacy
  • * Acute brain infection (e.g., neurosyphilis, toxoplasmosis)
  • * Acutely symptomatic bipolar I or psychotic disorder
  • * Prescription for immunomodulatory medications or other immunotherapy
  • * Any MRI contraindications
  • * If applicable, on antidepressant medication regimen for at least 2 months

Ages Eligible for Study

18 Years to 59 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Wake Forest University Health Sciences,

Christina S Meade, PhD, PRINCIPAL_INVESTIGATOR, Wake Forest University Health Sciences

Adam W Carrico, PhD, PRINCIPAL_INVESTIGATOR, Florida International University

Study Record Dates

2028-12-31