RECRUITING

TURN-IT FOG: Improving Turning and Freezing of Gait in People With PD

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goals of this clinical trial are to 1) learn how two different rehabilitation interventions for PD can reduce Freezing of Gait (FOG) in people with Parkinson's disease, as assessed by patients, clinicians, and wearable sensors, and 2) to explore whether two different rehabilitation intervention can reduce FOG and improve daily life mobility in people with FOG sufficiently to justify a clinical trial. Participants will: * Be randomly assigned to one of two intervention groups (turning-focused agility exercise or strength-based exercise) * Have one-on-one training sessions three times per week for 6 weeks * Perform in-lab assessments before beginning and after completing the study intervention * Use wearable mobility sensors during daily life to measure their walking and balance

Official Title

TURN-IT FOG: A Novel Intervention to Improve Turning in People With PD and Freezing of Gait

Quick Facts

Study Start:2025-06-02
Study Completion:2027-06-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06815302

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:50 Years to 80 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * diagnosis of idiopathic PD from movement disorders neurologist with the United Kingdom Brain Bank criteria of bradykinesia with one or more of the following - rest tremor, rigidity, and balance problems not from visual, vestibular, cerebellar or proprioceptive conditions
  2. * reporting FOG in the New Freezing of Gait questionnaire (N-FOGQ)
  3. * Hoehn \& Yahr stages II-IV
  4. * ages 50-80 years old
  5. * cognitive ability sufficient to participate in testing procedures and exercise classes
  6. * be willing and able to participate in exercise intervention 3x/week for 6 weeks
  1. * Major musculoskeletal or neurological disorders, structural brain disease, epilepsy, acute illness or health history, other than PD, significantly affecting gait and turning (i.e., musculoskeletal disorder, vestibular problem, head injury, stroke, cardiac disease)
  2. * medical condition or medications that precludes moderate-intensity exercise
  3. * Montreal Cognitive Assessment (MoCA) ≤21 or inability to follow directions
  4. * excessive use of alcohol or recreational drugs
  5. * recent change in medication
  6. * inability to stand and walk for 2 minutes without an assistive device

Contacts and Locations

Study Contact

Graham R Harker, MPH
CONTACT
(503) 418-2601
harkerg@ohsu.edu

Principal Investigator

Martina Mancini, PhD
PRINCIPAL_INVESTIGATOR
Oregon Health and Science University

Study Locations (Sites)

Arizona State University
Tempe, Arizona, 85281
United States
Oregon Health and Science University
Portland, Oregon, 97239
United States

Collaborators and Investigators

Sponsor: Oregon Health and Science University

  • Martina Mancini, PhD, PRINCIPAL_INVESTIGATOR, Oregon Health and Science University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-06-02
Study Completion Date2027-06-30

Study Record Updates

Study Start Date2025-06-02
Study Completion Date2027-06-30

Terms related to this study

Additional Relevant MeSH Terms

  • Parkinson Disease
  • Freezing of Gait Symptoms in Parkinson Disease