Gastric Feeding Versus Transpyloric Feeding in Infants with Severe Bronchopulmonary Dysplasia, a Crossover Study

Description

Hospitalized infants with severe bronchopulmonary dysplasia (BPD) and feeding intolerance will be randomized to 2 weeks of continuous gastric feeding or continuous transpyoloric feeding. Subjects will crossover after 2 weeks and receive 4 weeks of each feeding mode. Respiratory status will be assessed to determine the optimal feeding mode for each infant.

Conditions

Bronchopulmonary Dysplasia, Feeding Intolerance

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Study Overview

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Study Details

Study overview

Hospitalized infants with severe bronchopulmonary dysplasia (BPD) and feeding intolerance will be randomized to 2 weeks of continuous gastric feeding or continuous transpyoloric feeding. Subjects will crossover after 2 weeks and receive 4 weeks of each feeding mode. Respiratory status will be assessed to determine the optimal feeding mode for each infant.

N-of-1 Trial Comparing Prolonged Gastric Feeding to Transpyloric Feeding in Infants with Severe Bronchopulmonary Dysplasia

Gastric Feeding Versus Transpyloric Feeding in Infants with Severe Bronchopulmonary Dysplasia, a Crossover Study

Condition
Bronchopulmonary Dysplasia
Intervention / Treatment

-

Contacts and Locations

Memphis

Le Bonheur Children's Hospital, Memphis, Tennessee, United States, 38103

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Patients born \<32 weeks' gestation
  • * Currently admitted to the Le Bonheur NICU
  • * Grad 2 or 3 BPD (positive pressure or intubated at 36 weeks PMA)
  • * Signs of gastroesophageal reflux, chronic aspiration, or other feeding intolerance.
  • * Known gastrointestinal anomalies
  • * Unable to tolerate ≥100mL/kg/day enteral feeding
  • * Congenital anomalies likely to alter feeding techniques
  • * Surgical feeding tube in place or expected within the next 8 weeks
  • * Expected to remain hospitalized \<8 weeks

Ages Eligible for Study

1 Month to 1 Year

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Le Bonheur Children's Hospital,

Mark Weems, MD, PRINCIPAL_INVESTIGATOR, University of Tennessee

Study Record Dates

2030-02