Intravenous Methadone Versus Intrathecal Morphine for Analgesia Following Cesarean Delivery

Description

The purpose of this study is to determine if there is a difference in opioid requirements at 0-48 hours after scheduled cesarean delivery in patients receiving 150 mcg intrathecal morphine compared to 0.2 mg/kg (maximum 20 mg) intravenous methadone.

Conditions

Cesarean Delivery

Talk to us

Study Overview

On this page

Study Details

Study overview

The purpose of this study is to determine if there is a difference in opioid requirements at 0-48 hours after scheduled cesarean delivery in patients receiving 150 mcg intrathecal morphine compared to 0.2 mg/kg (maximum 20 mg) intravenous methadone.

Intravenous Methadone Versus Intrathecal Morphine for Analgesia Following Cesarean Delivery: a Randomized Clinical Trial

Intravenous Methadone Versus Intrathecal Morphine for Analgesia Following Cesarean Delivery

Condition
Cesarean Delivery
Intervention / Treatment

-

Contacts and Locations

Rochester

Mayo Clinic in Rochester, Rochester, Minnesota, United States, 55905

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * English-speaking
  • * Age over 18 years old
  • * Scheduled cesarean delivery
  • * Any contraindication to the administration of a spinal technique for anesthesia
  • * History of intolerance or adverse reaction to opioid medications
  • * History of chronic pain, opioid use \>30 OME/day, or substance use disorder
  • * History of obstructive sleep apnea, chronic obstructive pulmonary disease, or respiratory compromise (SpO2 \<92% on room air, or has a pre-existing oxygen requirement)
  • * History of liver or kidney failure
  • * Diagnosis of pre-eclampsia with current pregnancy
  • * Depression requiring more than one medication
  • * Planned use of CSE technique
  • * BMI \>50.0 kg/m2
  • * ASA status IV, V
  • * No prior history of an ECG demonstrating QTc \> 440ms
  • * Surgical complication requiring conversion to general anesthesia

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Mayo Clinic,

Emily E Sharpe, M.D., PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

2025-11-07