RECRUITING

Nasal Obstruction With Oxymetazoline and Corticosteroids

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study aims to examine the efficacy and safety of commination oxymetazoline/intranasal steroids for long-term management of chronic nasal obstruction that is recalcitrant to the current standard of care. The investigators hypothesize that combination treatment with oxymetazoline and intranasal corticosteroid spray will provide a larger reduction in nasal obstruction than intranasal corticosteroid alone for patients suffering from chronic nasal obstruction, and there will not be occurrences of rhinitis medicamentosa.

Official Title

Nasal Obstruction Randomized Trial With Oxymetazoline and Corticosteroids

Quick Facts

Study Start:2024-10-15
Study Completion:2025-07-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06830109

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. males and females ages 18 years or older
  2. 2. have a history of nasal obstruction
  3. 3. have failed a trial of topical steroids (that included at least 1 month of daily use)
  4. 4. ability to read, write, and understand English
  5. 5. either do not desire surgery or are poor surgical candidates due to medical comorbidities.
  6. 6. Patients who have had prior use of oxymetazoline or other nasal decongestants are eligible for the study but must have stopped usage 4 weeks prior to randomization.
  7. 1. Must be willing to stop using any other nasal sprays, besides saline, and oral decongestants.
  1. 1. Any history of sinonasal mass/tumor
  2. 2. Any history of nasal polyps
  3. 3. a known history of chronic sinusitis
  4. 4. an allergy to oxymetazoline
  5. 5. or who have any medical contraindication to oxymetazoline use, such as pulmonary hypertension.

Contacts and Locations

Study Contact

Nyssa Farrell, MD
CONTACT
314-362-7509
nyssa.farrell@wustl.edu
Lucas Cruz, BA
CONTACT
314-362-0549
lucascruz@wustl.edu

Principal Investigator

Nyssa F Farrell, MD
PRINCIPAL_INVESTIGATOR
Washington University School of Medicine

Study Locations (Sites)

Washington University
Saint Louis, Missouri, 63110
United States

Collaborators and Investigators

Sponsor: Washington University School of Medicine

  • Nyssa F Farrell, MD, PRINCIPAL_INVESTIGATOR, Washington University School of Medicine

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-10-15
Study Completion Date2025-07-30

Study Record Updates

Study Start Date2024-10-15
Study Completion Date2025-07-30

Terms related to this study

Keywords Provided by Researchers

  • Oxymetazoline
  • Corticosteroids
  • Chronic rhinitis

Additional Relevant MeSH Terms

  • Nasal Obstruction