RECRUITING

Bleeding Patterns in Sequential and Continuous Progesterone Supplementation in Adolescents With Turner Syndrome

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Conditions

Turner SyndromePrimary Ovarian Insufficiency (Poi)Primary ovarian insufficiencyHormone replacement therapy

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This is a single-site open label non-randomized study comparing effects of sequential versus continuous use of progesterone supplementation amongst Turner Syndrome (TS) patients with primary ovarian insufficiency (POI) prescribed hormone replacement therapy (HRT).

Official Title

Bleeding Patterns in Sequential and Continuous Progesterone Supplementation in Adolescents With Turner Syndrome: A Non-randomized Prospective Trial (The BOOST Study)

Quick Facts

Study Start:2025-07-31
Study Completion:2026-07-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06834594

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:12 Years to 20 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:No
Standard Ages:CHILD, ADULT
Inclusion CriteriaExclusion Criteria
  1. * Diagnosis of Turner Syndrome and Primary Ovarian Insufficiency.
  2. * Prescribed adult dosing\* of transdermal or oral estradiol for estrogen replacement therapy.
  3. * Have achieved menarche.
  1. * Disclosure of sexual activity and desire for contraception.
  2. * Having a levonorgestrel-releasing intrauterine device or etonogestrel arm implant in place.
  3. * Having received depot medroxyprogesterone within one year prior to study recruitment.
  4. * Non-English or non-Spanish speaking.

Contacts and Locations

Study Contact

Allie Ranallo
CONTACT
+1-816-394-7534
alranallo@cmh.edu
Andrea Manlove
CONTACT
+1-816-731-7326
almanlove@cmh.edu

Principal Investigator

Tazim Dowlut-McElroy, M.D., M.S.
PRINCIPAL_INVESTIGATOR
Children's Mercy Kansas City

Study Locations (Sites)

Children's Mercy Hospital
Kansas City, Missouri, 64108
United States

Collaborators and Investigators

Sponsor: Children's Mercy Hospital Kansas City

  • Tazim Dowlut-McElroy, M.D., M.S., PRINCIPAL_INVESTIGATOR, Children's Mercy Kansas City

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-07-31
Study Completion Date2026-07-31

Study Record Updates

Study Start Date2025-07-31
Study Completion Date2026-07-31

Terms related to this study

Keywords Provided by Researchers

  • Turner syndrome
  • Primary ovarian insufficiency
  • Hormone replacement therapy

Additional Relevant MeSH Terms

  • Turner Syndrome
  • Primary Ovarian Insufficiency (Poi)