RECRUITING

Volatility in Paranoia

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Conditions

Schizophrenia DisordersSchizophreniaDelusionParanoiaPsychotherapyBeliefsVolatilityCognitive Behavioral TherapyCBTpPsychosis

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical trial is to learn whether learning and belief updating change in response to the treatment of persecutory delusions, in individuals with schizophrenia-spectrum disorders. The main questions are: 1. do prior expectations about environmental volatility reduce following effective psychotherapeutic treatment of delusions? 2. does corresponding brain activity related to volatility change with effective treatment of delusions? Participants will: 1. engage in CBTp or TAU + phone check-ins for 16 weeks 2. complete assessments at 4 timepoints over the course of 6 months 3. complete an MRI when possible

Official Title

Testing the Role of Belief Updating in Persecutory Delusions

Quick Facts

Study Start:2025-01-15
Study Completion:2029-10
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06835556

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Men and women age 18 - 65.
  2. * Communicative in English.
  3. * Premorbid IQ \>79 (WTAR)
  4. * Provide voluntary, written informed consent.
  5. * Stable medication regimen over at least the past two weeks, including the use of either an oral or intramuscular administration of an antipsychotic medication.
  6. * Diagnosis of a non-affective psychotic disorder (e.g. schizophrenia, schizoaffective disorder, schizophreniform disorder, delusional disorder)
  7. * A persecutory delusion scoring at least a 3 on the conviction scale of the Psychotic Symptoms Rating Scale (PSYRATS) that had persisted for at least two months and that was not considered the direct result of substance use.
  1. * Serious medical or neurological illness known to interfere with cognitive functioning (uncontrolled/unstable diabetes, uncontrolled hypothyroidism, Cushing's disease, Lupus, any demyelinating disease such as Multiple Sclerosis, HIV infection, CNS infection, unstable heart disease, active hepatitis, other significant endocrine condition, any cancer involving the CNS/brain, any uncorrected vision problems, tardive dyskinesia).
  2. * History of severe head trauma with loss of consciousness \>30 minutes.
  3. * Primary diagnosis of alcohol or substance use disorder or personality disorder

Contacts and Locations

Study Contact

Julia Sheffield, PhD
CONTACT
615-343-3839
julia.sheffield@vumc.org

Study Locations (Sites)

Vanderbilt University Medical Center
Nashville, Tennessee, 37212
United States

Collaborators and Investigators

Sponsor: Vanderbilt University Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-01-15
Study Completion Date2029-10

Study Record Updates

Study Start Date2025-01-15
Study Completion Date2029-10

Terms related to this study

Keywords Provided by Researchers

  • Schizophrenia
  • Delusion
  • Paranoia
  • Psychotherapy
  • Beliefs
  • Volatility
  • Cognitive Behavioral Therapy
  • CBTp
  • Psychosis

Additional Relevant MeSH Terms

  • Schizophrenia Disorders