RECRUITING

Biomarkers for Cognitive Decline in Intracerebral Hemorrhage

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical trial is to see if silent brain infarcts (SBIs), or stroke-like symptoms detectable during brain imaging, are a possible contributor to cognitive decline for patients diagnosed with spontaneous intracerebral hemorrhage (sICH), or blood clot in the brain. The main questions it aims to answer are * if SBIs in sICH are associated with a lower cognitive level and more rapid cognitive decline * if SBIs in sICH are associated with certain findings on brain imaging * if SBIs in sICH are associated with higher inflammation measured by certain blood tests Participants will undergo * cognitive testing during hospitalization, and at 3, 6 and 12 months after the sICH * Magnetic Resonance Imaging (MRI) of the brain during hospitalization and 12 months after the sICH * blood draws during hospitalization and at 3, 6 and 12 months after the sICH

Official Title

Silent Brain Infarcts in Spontaneous Intracerebral Hemorrhage as a Prognostic Biomarker for Vascular Contributions to Cognitive Impairment and Dementia (VCID)

Quick Facts

Study Start:2025-08-02
Study Completion:2029-08-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06836141

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 80 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Primary Intracerebral Hemorrhage
  2. * Age ≥ 18 and \< 80 years
  1. * ICH score \> 2
  2. * Pre-existing dementia
  3. * Prior history of stroke
  4. * Neurosurgical evacuation of hematoma

Contacts and Locations

Study Contact

Amanda Sremac, BS
CONTACT
312-942-0593
Amanda_C_Sremac@rush.edu
Rajeev Garg, MD
CONTACT
Rajeev_Garg@rush.edu

Principal Investigator

Rajeev Garg, MD
PRINCIPAL_INVESTIGATOR
Rush University Medical Center

Study Locations (Sites)

Rush University Medical Center
Chicago, Illinois, 60614
United States

Collaborators and Investigators

Sponsor: Rush University Medical Center

  • Rajeev Garg, MD, PRINCIPAL_INVESTIGATOR, Rush University Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-08-02
Study Completion Date2029-08-01

Study Record Updates

Study Start Date2025-08-02
Study Completion Date2029-08-01

Terms related to this study

Additional Relevant MeSH Terms

  • Primary Intracerebral Hemorrhage