RECRUITING

Osteopathic Manual Therapy (OMT) and Brain Structure and Function in Primary Headache Patients: A Pilot Study

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Chronic headaches are associated with changes in brain structure and function that may be associated with increased suffering and disability. Understanding how Osteopathic Manipulative Therapy (OMT) affects these changes would reveal new insight into how the brain processes pain and returns to normal function. Also, demonstrating these changes would provide evidence regarding how OMT causes a reduction in pain and disability, supporting the recommendation for OMT as a primary treatment option for headaches.

Official Title

Exploring the Mechanism of Osteopathic Manual Therapy (OMT) on Brain Structure and Function in Primary Headache Patients: A Pilot Study

Quick Facts

Study Start:2025-08-05
Study Completion:2026-04
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06841627

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 60 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * current diagnosis of primary headache (migraine, tension-type, cluster) from a healthcare provider
  2. * have experienced at least one headache episode a month for the previous 1 year (or longer)
  3. * age of PH onset was less than 50 years, currently taking medication for headaches.
  1. * presence of headaches due to some other underlying medical condition (secondary headaches)
  2. * traumatic brain injury
  3. * fibromyalgia, epilepsy
  4. * diagnosis of a neurodegenerative disorder
  5. * history of brain tumor or cancer
  6. * history of cervical radiculopathy (pinched nerve in the neck)
  7. * currently undergoing manual therapy type treatment or have a a treatment within 2 weeks of enrollment(chiropractic, OMT, massage, PT)
  8. * currently pregnant
  9. * have had an injection to treat headaches within the previous 3 months from study enrollment
  10. * contraindications to MRI.

Contacts and Locations

Study Contact

Daniel Cawley, DC, MS
CONTACT
1334-442-4105
dcawley@vcom.edu
Adil Bashir, PhD
CONTACT
azb0117@auburn.edu

Principal Investigator

Daniel Cawley, DC
PRINCIPAL_INVESTIGATOR
Edward Via College of Osteopathic Medicine

Study Locations (Sites)

Auburn University MRI Center and Edward Via College of Medicine
Auburn, Alabama, 36832
United States

Collaborators and Investigators

Sponsor: Edward Via Virginia College of Osteopathic Medicine

  • Daniel Cawley, DC, PRINCIPAL_INVESTIGATOR, Edward Via College of Osteopathic Medicine

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-08-05
Study Completion Date2026-04

Study Record Updates

Study Start Date2025-08-05
Study Completion Date2026-04

Terms related to this study

Keywords Provided by Researchers

  • Migraine
  • Headaches
  • Osteopathic Manipulative Treatment
  • Brain
  • OMT

Additional Relevant MeSH Terms

  • Primary Headaches (Migraines, Tension, Cluster Headaches)