RECRUITING

Transcranial Magnetic Stimulation + Language Therapy to Treat Mild Aphasia

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with Speech-Language Therapy (SLT) is an effective treatment for mild aphasia in persons with chronic stroke. The main questions this study aims to answer are: 1. Can TMS combined with SLT improve conversational speech and comprehension? 2. Can we identify specific behavioral and biological characteristics that would benefit most from the TMS and SLT treatment? Researchers will compare real TMS to sham (fake) TMS to see whether TMS can treat post-stroke mild aphasia. Participants will: * Complete a screening and medical intake to determine eligibility * Undergo a MRI * Participate in 10 consecutive sessions (Monday-Friday) of TMS and SLT treatment * Complete follow-up assessments 2 and 4 months after treatment

Official Title

Personalized Transcranial Magnetic Stimulation and Constraint Induced Language Therapy to Treat Mild Post-Stroke Aphasia

Quick Facts

Study Start:2025-02-11
Study Completion:2026-08-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06842745

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:40 Years to 85 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Left Hemisphere stroke
  2. * Stroke occurred more than 6 months ago
  3. * Mild Aphasia (WAB AQ score \> 85)
  4. * Proficient in English
  1. * Ongoing substance or alcohol abuse
  2. * Other neurological disorders, beside stroke (i.e. dementia, traumatic brain injury, multiple sclerosis)
  3. * Active psychiatric disorders (i.e. bipolar disorder, schizophrenia)
  4. * Pacemaker or cardiac defibrillator
  5. * Diagnosis of tinnitus
  6. * Epilepsy, or seizure in the past 6 months

Contacts and Locations

Study Contact

Harris Drachman, MS
CONTACT
215-964-2502
harris.drachman@pennmedicine.upenn.edu
Daniela Sacchetti, MS
CONTACT
danielas@pennmedicine.upenn.edu

Principal Investigator

H. Branch Coslett, MD
PRINCIPAL_INVESTIGATOR
University of Pennsylvania

Study Locations (Sites)

University of Pennsylvania
Philadelphia, Pennsylvania, 19014
United States

Collaborators and Investigators

Sponsor: University of Pennsylvania

  • H. Branch Coslett, MD, PRINCIPAL_INVESTIGATOR, University of Pennsylvania

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-02-11
Study Completion Date2026-08-31

Study Record Updates

Study Start Date2025-02-11
Study Completion Date2026-08-31

Terms related to this study

Keywords Provided by Researchers

  • aphasia
  • stroke
  • non-invasive brain stimulation
  • Transcranial Magnetic Stimulation

Additional Relevant MeSH Terms

  • Aphasia
  • Stroke
  • Aphasia Following Cerebral Infarction
  • Aphasia, Acquired