Transcranial Magnetic Stimulation + Language Therapy to Treat Mild Aphasia

Description

The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with Speech-Language Therapy (SLT) is an effective treatment for mild aphasia in persons with chronic stroke. The main questions this study aims to answer are: 1. Can TMS combined with SLT improve conversational speech and comprehension? 2. Can we identify specific behavioral and biological characteristics that would benefit most from the TMS and SLT treatment? Researchers will compare real TMS to sham (fake) TMS to see whether TMS can treat post-stroke mild aphasia. Participants will: * Complete a screening and medical intake to determine eligibility * Undergo a MRI * Participate in 10 consecutive sessions (Monday-Friday) of TMS and SLT treatment * Complete follow-up assessments 2 and 4 months after treatment

Conditions

Aphasia, Stroke, Aphasia Following Cerebral Infarction, Aphasia, Acquired

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Study Details

Study overview

The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with Speech-Language Therapy (SLT) is an effective treatment for mild aphasia in persons with chronic stroke. The main questions this study aims to answer are: 1. Can TMS combined with SLT improve conversational speech and comprehension? 2. Can we identify specific behavioral and biological characteristics that would benefit most from the TMS and SLT treatment? Researchers will compare real TMS to sham (fake) TMS to see whether TMS can treat post-stroke mild aphasia. Participants will: * Complete a screening and medical intake to determine eligibility * Undergo a MRI * Participate in 10 consecutive sessions (Monday-Friday) of TMS and SLT treatment * Complete follow-up assessments 2 and 4 months after treatment

Personalized Transcranial Magnetic Stimulation and Constraint Induced Language Therapy to Treat Mild Post-Stroke Aphasia

Transcranial Magnetic Stimulation + Language Therapy to Treat Mild Aphasia

Condition
Aphasia
Intervention / Treatment

-

Contacts and Locations

Philadelphia

University of Pennsylvania, Philadelphia, Pennsylvania, United States, 19014

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Left Hemisphere stroke
  • * Stroke occurred more than 6 months ago
  • * Mild Aphasia (WAB AQ score \> 85)
  • * Proficient in English
  • * Ongoing substance or alcohol abuse
  • * Other neurological disorders, beside stroke (i.e. dementia, traumatic brain injury, multiple sclerosis)
  • * Active psychiatric disorders (i.e. bipolar disorder, schizophrenia)
  • * Pacemaker or cardiac defibrillator
  • * Diagnosis of tinnitus
  • * Epilepsy, or seizure in the past 6 months

Ages Eligible for Study

40 Years to 85 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Pennsylvania,

H. Branch Coslett, MD, PRINCIPAL_INVESTIGATOR, University of Pennsylvania

Study Record Dates

2026-08-31