A Drug-Drug Interaction Study to Evaluate the Effects of Itraconazole, Carbamazepine, Quinidine and Fluconazole on the Pharmacokinetics and Safety of EDP-323.

Eligibility Criteria

• * An informed consent document signed and dated by the subject.
• * Healthy male and female subjects of any ethnic origin between the ages of 18 and 65 years, inclusive.
• * Screening body mass index (BMI) of 18 to 30 kg/m2 with a minimum body weight of50 kg
• * Female subjects of childbearing potential must agree to use two effective methods of contraception from the date of Screening until 30 days after the last dose of EDP-323. A male participant who has not had a vasectomy and is sexually active with a woman of childbearing potential must agree to use effective contraception from the date of Screening to 90 days after his last dose of study drug.
• * Clinically relevant evidence or history of illness or disease
• * Pregnant or nursing females
• * History of febrile illness within 7 days prior to the first dose of study drug or subjects with evidence of active infection
• * A positive urine drug screen at Screening or Day -1
• * Current tobacco smokers or use of tobacco within 3 months prior to Screening.
• * Any condition possibly affecting drug absorption (e.g., gastrectomy, cholecystectomy)
• * History of regular alcohol consumption exceeding protocol limits
• * Participation in a clinical trial within 28 days prior to the first dose of study drug
• * For Part 2 and Part 3 participants, the following cardiovascular abnormalities:
• * QRS duration \>110 ms
• * Incomplete right bundle branch block or any complete bundle branch block
• * Heart rate \<40 or \>90 beats per minute (per vital sign capture while rested)
• * History of unexplained syncope, structural heart disease, or clinically significant arrhythmias
• * Personal or family history of long QT syndrome (genetically proven or suggested by sudden death of a close relative due to cardiac causes at a young age) or Brugada syndrome
• * PR interval \>220 ms or any 2nd or 3rd degree AV block
• * Ventricular pre-excitation
• * Other exclusions for Part 2 (carbamazepine) participants
• * Participants of Asian ancestry with HLA allele B\*1502 in this population
• * Platelets, white blood cell count or hemoglobin below the lower limit of normal, due to reported incidence of agranulocytosis and aplastic anemia with carbamazepine