RECRUITING

Families Left Behind

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The United States is facing unprecedented rates of drug overdose deaths, profoundly impacting millions of families who are left to navigate their grief. Those bereaved by overdose experience a unique form of grief characterized by feelings of guilt, shame, and blame, which can worsen their suffering and deter them from seeking help. Individuals coping with overdose loss often endure more severe health consequences compared to those grieving non-drug related deaths, including prolonged grief disorder, substance use disorders, PTSD, depression, and suicidal thoughts. Moreover, bereaved individuals, particularly those with a history of substance use, may engage in risky behaviors as a means of coping, further exacerbating the risk of overdose and mortality within this vulnerable population. Peer grief support interventions have emerged as a promising approach to assist those experiencing such losses. To combat these outcomes, we are collaborating with Peer Community Support Partners (PSCP) in a novel practice-research partnership to implement the RIVER peer grief support model. Though RIVER has shown success in community settings, it has yet to be rigorously evaluated. In a three-aim approach, this study aims to assess the effectiveness of the RIVER model while also enhancing and engaging grievers with support resources via medical examiner offices (MEOs), which routinely contact families during death investigations. This research represents a pivotal advancement in addressing the needs of the overlooked bereaved community, aligning with the NIH's Helping to End Addiction Long-term (HEAL) initiative to develop effective strategies against the opioid crisis. Together, community engagement and rigorous research efforts aim to enhance support for those affected by the tragedy of drug overdose.

Official Title

Families Left Behind: Addressing Prolonged Grief and Substance Use Disorders Among People Bereaved by Drug Overdose Deaths

Quick Facts

Study Start:2025-06-13
Study Completion:2030-10
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06854757

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * people who lost a loved one to an unintentional drug overdose death within the past year
  2. * age 18 and older
  3. * fluently understand English or Spanish
  4. * have the capacity to give consent (e.g., excluding those with severe cognitive impairment, those in active psychosis, and those with developmental disabilities).
  1. * people who need hospitalization for psychiatric symptoms or substance use disorders. (Note, people who use drugs but who do not require hospitalization will be included.)
  2. * people have active suicidal ideation
  3. * people who lost someone to a drug overdose death more than one year ago
  4. * people who lost someone to a drug overdose death that was suicidal in nature or of undetermined intent

Contacts and Locations

Study Contact

Alison Athey, PhD
CONTACT
(703) 413-1100
aathey@rand.org
Karen Osilla, PhD
CONTACT
kosilla@stanford.edu

Principal Investigator

Alison Athey, PhD
PRINCIPAL_INVESTIGATOR
RAND
Karen Osilla, PhD
PRINCIPAL_INVESTIGATOR
Stanford University

Study Locations (Sites)

Jefferson County Coroner/Medical Examiner's Office
Birmingham, Alabama, 35203
United States
San Diego County Medical Examiner Office
San Diego, California, 92123
United States
Connecticut Office of the Chief Medical Examiner
Farmington, Connecticut, 06032
United States
Peer Support Community Partners
Watertown, Massachusetts, 02472
United States

Collaborators and Investigators

Sponsor: RAND

  • Alison Athey, PhD, PRINCIPAL_INVESTIGATOR, RAND
  • Karen Osilla, PhD, PRINCIPAL_INVESTIGATOR, Stanford University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-06-13
Study Completion Date2030-10

Study Record Updates

Study Start Date2025-06-13
Study Completion Date2030-10

Terms related to this study

Keywords Provided by Researchers

  • overdose
  • grief
  • bereavement
  • prolonged grief disorder

Additional Relevant MeSH Terms

  • Grief
  • Grief Disorder, Prolonged
  • Overdose Accidental
  • Substance Use Disorders