COMPLETED

Effect of Patient Preference for Intraoperative Opioid Use on Early Postoperative Quality of Recovery

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Substituting the administration of opioids with a combination of alternative analgesics, known as opioid-free anesthesia (OFA), is gaining in popularity today and is typically administered as part of a larger multimodal strategy. However, OFA adoption is not as common today as one could expect from the potential benefits of limiting opioid use and patient involvement in the decision may impact its adoption. Relevant shared decision-making process with patients concerning the use or limited use of opioids could improve patient autonomy and empowerment. There have been no studies that have evaluated patient preference regarding opioid use and its potential impact on the quality of recovery. The aim of this study is to compare the effect of patient preference on intraoperative opioid use on early postoperative quality of recovery following moderate risk laparoscopic/robotic abdominal surgery.

Official Title

Patient Preference for Intraoperative Opioid Use and Early Recovery Following Non-Cardiac Surgery: Protocol for a Randomized Factorial Design Trial of Opioid-Free vs Opioid-Based Anesthesia (PERFECT TRIAL)

Quick Facts

Study Start:2025-03-24
Study Completion:2025-06-18
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT06855641

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age \>18 years.
  2. * Undergoing elective intermediate risk surgery under general anesthesia (robotic or laparoscopic assisted urological, gynecological or abdominal surgery).
  3. * American Society Anesthesiologists physical status classification system grades of I-IV.
  4. * English speaking.
  5. * Informed consent signed.
  1. * Diagnosis of chronic pain
  2. * Preoperative prescribed opioids
  3. * Pregnancy or lactation.
  4. * History of mental disorders.
  5. * Contraindications to study drug (lidocaine, magnesium, dexmedetomidine, ketamine)
  6. * Patient is participating in another interventional trial
  7. * Patient is under judicial protection or is an adult under guardianship.

Contacts and Locations

Principal Investigator

Alexandre JOOSTEN, MD PhD
PRINCIPAL_INVESTIGATOR
University of California, Los Angeles

Study Locations (Sites)

Ronald Reagan UCLA Medical Center
Los Angeles, California, 90095
United States
UCLA Ronald Reagan medical center
Los Angeles, California, 90095
United States

Collaborators and Investigators

Sponsor: University of California, Los Angeles

  • Alexandre JOOSTEN, MD PhD, PRINCIPAL_INVESTIGATOR, University of California, Los Angeles

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-03-24
Study Completion Date2025-06-18

Study Record Updates

Study Start Date2025-03-24
Study Completion Date2025-06-18

Terms related to this study

Keywords Provided by Researchers

  • opioids
  • quality of recovery
  • analgesia
  • moderate risk surgery
  • postoperative pain

Additional Relevant MeSH Terms

  • Opioid Analgesia
  • Quality of Recovery (QoR-15)
  • Outcome Assessment
  • Opioid Free Anesthesia