RECRUITING

Feasibility of Resting Intervals During Exercise Programs for Individuals with Knee Osteoarthritis

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Conditions

Knee OsteoarthristisKneeOsteoarthritisexercisefeasibility

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This pilot randomize trial tests the feasibility of administering two different exercise programs in people with knee osteoarthritis. One group receives the exercise program administered as usual, and the other group received the exercise program with resting intervals.

Official Title

Mechanical and Molecular Determinants of Cartilage Response to Exercise

Quick Facts

Study Start:2024-12-04
Study Completion:2026-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06857123

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:45 Years to 79 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age between 45 and 79 yo.
  2. * Clinical diagnosis of primary, early to moderate stage knee osteoarthritis.
  3. * BMI range of 25 to 35 kg/m2.
  4. * Sedentary lifestyle
  5. * Knee joint is the most painful joint in the body.
  6. * Ability to speak and understand English.
  7. * Willingness to comply with all study procedures and be available for the duration of the study.
  1. * Non-OA disease of the knee.
  2. * Advanced knee osteoarthritis
  3. * Knee injection in the past 3 months.
  4. * Major knee trauma/surgery in the past 5 years or previous knee surgery with hardware limiting cartilage assessment..
  5. * Participate in regular exercise or physical activity .
  6. * Participation in an intervention study for knee OA.
  7. * Currently using a cane, walker or crutches to walk.
  8. * History of cardiovascular disease or hypertension not controlled by medication.
  9. * Two or more unexplained falls in the past year.
  10. * Inflammatory, autoimmune disorders, neurological, systemic, muscular, or connective tissue conditions that affect walking or ability to exercise.
  11. * Contraindication to MRI.
  12. * Medical condition or characteristic of the participant that could place the individual at increased risk or preclude s/he from complying with study procedures.
  13. * Pregnant female.
  14. * Acute or terminal illness.

Contacts and Locations

Study Contact

Gaupp
CONTACT
412-383-0742
awg26@pitt.edu

Principal Investigator

Sara Piva
PRINCIPAL_INVESTIGATOR
University of Pittsburgh

Study Locations (Sites)

University of Pittsburgh
Pittsburgh, Pennsylvania, 15213
United States

Collaborators and Investigators

Sponsor: University of Pittsburgh

  • Sara Piva, PRINCIPAL_INVESTIGATOR, University of Pittsburgh

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-12-04
Study Completion Date2026-01

Study Record Updates

Study Start Date2024-12-04
Study Completion Date2026-01

Terms related to this study

Keywords Provided by Researchers

  • Knee
  • Osteoarthritis
  • exercise
  • feasibility

Additional Relevant MeSH Terms

  • Knee Osteoarthristis