Feasibility of Resting Intervals During Exercise Programs for Individuals with Knee Osteoarthritis

Description

This pilot randomize trial tests the feasibility of administering two different exercise programs in people with knee osteoarthritis. One group receives the exercise program administered as usual, and the other group received the exercise program with resting intervals.

Conditions

Knee Osteoarthristis

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Study Overview

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Study Details

Study overview

This pilot randomize trial tests the feasibility of administering two different exercise programs in people with knee osteoarthritis. One group receives the exercise program administered as usual, and the other group received the exercise program with resting intervals.

Mechanical and Molecular Determinants of Cartilage Response to Exercise

Feasibility of Resting Intervals During Exercise Programs for Individuals with Knee Osteoarthritis

Condition
Knee Osteoarthristis
Intervention / Treatment

-

Contacts and Locations

Pittsburgh

University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 15213

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age between 45 and 79 yo.
  • * Clinical diagnosis of primary, early to moderate stage knee osteoarthritis.
  • * BMI range of 25 to 35 kg/m2.
  • * Sedentary lifestyle
  • * Knee joint is the most painful joint in the body.
  • * Ability to speak and understand English.
  • * Willingness to comply with all study procedures and be available for the duration of the study.
  • * Non-OA disease of the knee.
  • * Advanced knee osteoarthritis
  • * Knee injection in the past 3 months.
  • * Major knee trauma/surgery in the past 5 years or previous knee surgery with hardware limiting cartilage assessment..
  • * Participate in regular exercise or physical activity .
  • * Participation in an intervention study for knee OA.
  • * Currently using a cane, walker or crutches to walk.
  • * History of cardiovascular disease or hypertension not controlled by medication.
  • * Two or more unexplained falls in the past year.
  • * Inflammatory, autoimmune disorders, neurological, systemic, muscular, or connective tissue conditions that affect walking or ability to exercise.
  • * Contraindication to MRI.
  • * Medical condition or characteristic of the participant that could place the individual at increased risk or preclude s/he from complying with study procedures.
  • * Pregnant female.
  • * Acute or terminal illness.

Ages Eligible for Study

45 Years to 79 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Pittsburgh,

Sara Piva, PRINCIPAL_INVESTIGATOR, University of Pittsburgh

Study Record Dates

2026-01