RECRUITING

WISE-2B Brain Study (Weight Loss Intervention Surgical Effects on Brain Function)

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of the study to understand the effects of weight loss and improvements in diabetes following bariatric surgery on brain function and thinking. This study will also examine whether non-invasive transcutaneous vagal nerve stimulation (tVNS) intervention initiated 30 days post-surgery improves brain function and thinking. The study does NOT cover any costs associated with bariatric surgery.

Official Title

Obesity and Type 2 Diabetes: Bariatric Surgery Effects on Brain Function -Part 2 (WISE-2B Brain Study)

Quick Facts

Study Start:2025-09
Study Completion:2027-09
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06861790

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:20 Years to 75 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Between age: 20-75 yrs, English speaking, Physically mobile
  2. * Body Mass Index (BMI) \>35 kg before surgery
  3. * Compatible of MRI Scanning
  4. * Willing to give a small blood sample
  5. * Capable of providing informed consent
  1. * Prior or current neurological disorder
  2. * Major psychiatric disturbance
  3. * Unstable medical conditions (cancer)
  4. * MRI contraindications (claustrophobia, metal implants, waist/torso circumference)

Contacts and Locations

Study Contact

Keyanni J Johnson
CONTACT
3522945618
kjjohnson@ufl.edu
Ronald Cohen, PhD
CONTACT
352-295-5840
roncohen@ufl.edu

Principal Investigator

Eric Porges, PhD
PRINCIPAL_INVESTIGATOR
University of Florida

Study Locations (Sites)

University of Florida - College of Public Health and Health Professions
Gainesville, Florida, 32611
United States

Collaborators and Investigators

Sponsor: University of Florida

  • Eric Porges, PhD, PRINCIPAL_INVESTIGATOR, University of Florida

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-09
Study Completion Date2027-09

Study Record Updates

Study Start Date2025-09
Study Completion Date2027-09

Terms related to this study

Keywords Provided by Researchers

  • Weight loss and brain function
  • Effects of bariatric surgery on brain function
  • Reduced glucose insulin changes and brain function
  • tVNS intervention post-surgery

Additional Relevant MeSH Terms

  • Diabetes
  • Weight Loss