ACTIVE_NOT_RECRUITING

A Study to Investigate Tonlamarsen for the Treatment of Adults With Uncontrolled Hypertension (KARDINAL)

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Conditions

Hypertension

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to evaluate the blood pressure (BP)-lowering efficacy of tonlamarsen in adult participants who, despite taking 2 or more antihypertensive medications, have not achieved their target blood pressure (BP).

Official Title

A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Monthly Subcutaneous Administration of Tonlamarsen in Participants With Uncontrolled Hypertension (KARDINAL)

Quick Facts

Study Start:2025-04-10
Study Completion:2026-03-06
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:ACTIVE_NOT_RECRUITING

Study ID

NCT06864104

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 80 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age 18 to 80, body weight ≥ 50 kg
  2. * Has uncontrolled hypertension while receiving between 2 and 5 antihypertensive medications prescribed for hypertension
  3. * Has mean office seated systolic blood pressure \> 135 to ≤ 170 mmHg
  1. * Has known history of secondary hypertension
  2. * Has documented history of poor adherence to antihypertensive medication
  3. * Has unstable/underlying known cardiovascular disease
  4. * Has abnormal thyroid function with clinical significance

Contacts and Locations

Study Locations (Sites)

Pinnacle Research Group
Anniston, Alabama, 36207
United States
Achieve Clinical Research, LLC
Birmingham, Alabama, 35216
United States
Elite Clinical Studies
Phoenix, Arizona, 85018
United States
Del Sol Research Management, LLC
Tucson, Arizona, 85715
United States
Cardiology and Medicine Clinic
Little Rock, Arkansas, 72204
United States
North Coast Cardiology
Encinitas, California, 92024
United States
Orange County Research Center
Lake Forest, California, 92630
United States
Clinical Trials Research
Lincoln, California, 95648
United States
American Institute of Research
Los Angeles, California, 90017
United States
Homestead Associates in Research, Inc.
Homestead, Florida, 33033
United States
Jacksonville Center for Clinical Research
Jacksonville, Florida, 32216
United States
Suncoast Clinical Research, Inc.
New Port Richey, Florida, 34652
United States
Progressive Medical Research
Port Orange, Florida, 32127
United States
Agile Clinical Research Trials, LLC
Atlanta, Georgia, 30328
United States
Velocity Clinical Reseach
Savannah, Georgia, 31406
United States
Eagle Clinical Research
Chicago, Illinois, 60621
United States
Clinical Investigation Specialists, Inc.
Gurnee, Illinois, 60031
United States
Koch Family Medicine Clinical Research
Morton, Illinois, 61550
United States
Tandem Clinical Research GI, LLC
Marrero, Louisiana, 70072
United States
IMA Clinical Research
Monroe, Louisiana, 71201
United States
DelRicht Clinical Research - New Orleans
New Orleans, Louisiana, 70115
United States
ActivMed Practices & Research, LLC
Methuen, Massachusetts, 01844
United States
Oakland Medical Research Center
Troy, Michigan, 48085
United States
Olive Branch Family Medical Center
Olive Branch, Mississippi, 38654
United States
Richmond University Medical Center
Staten Island, New York, 10310
United States
CHEAR Center LLC
The Bronx, New York, 10455
United States
IMA Clinical Research
Lenoir, North Carolina, 28645
United States
Clinical Trials of South Carolina
Moncks Corner, South Carolina, 29461
United States
Health Concepts
Rapid City, South Dakota, 57702
United States
Holston Medical Group
Kingsport, Tennessee, 37660
United States
Central Texas Clinical Research
Austin, Texas, 78705
United States
Advanced Medical Trials, LLC
Georgetown, Texas, 78628
United States
Juno Research, LLC
Houston, Texas, 77040
United States
Radiance Clinical Research
Lampasas, Texas, 76550
United States
Synergy Groups Medical, LLC
Missouri City, Texas, 77459
United States
North Hills Medical Research
North Richland Hills, Texas, 76180
United States
Sun Research Institute
San Antonio, Texas, 78215
United States
Manassas Clinical Research Center
Manassas, Virginia, 20110
United States
York Clinical Research LLC
Norfolk, Virginia, 23504
United States

Collaborators and Investigators

Sponsor: Kardigan, Inc.

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-04-10
Study Completion Date2026-03-06

Study Record Updates

Study Start Date2025-04-10
Study Completion Date2026-03-06

Terms related to this study

Additional Relevant MeSH Terms

  • Hypertension