A Study to Investigate Tonlamarsen for the Treatment of Adults with Uncontrolled Hypertension

Description

The purpose of this study is to evaluate the blood pressure-lowering effect of tonlamarsen in adult participants who, despite taking 2 or more antihypertensive medications, have not achieved their target blood pressure (BP).

Conditions

Hypertension

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Study Overview

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Study Details

Study overview

The purpose of this study is to evaluate the blood pressure-lowering effect of tonlamarsen in adult participants who, despite taking 2 or more antihypertensive medications, have not achieved their target blood pressure (BP).

A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Long-Term Safety of Monthly Subcutaneous Administration of Tonlamarsen in Participants with Uncontrolled Hypertension

A Study to Investigate Tonlamarsen for the Treatment of Adults with Uncontrolled Hypertension

Condition
Hypertension
Intervention / Treatment

-

Contacts and Locations

Phoenix

Elite Clinical Studies, Phoenix, Arizona, United States, 85018

Lincoln

Clinical Trials Research, Lincoln, California, United States, 95648

Port Orange

Progressive Medical Research, Port Orange, Florida, United States, 32127

New Orleans

DelRicht Clinical Research - New Orleans, New Orleans, Louisiana, United States, 70115

Bronx

Chear Center LLC, Bronx, New York, United States, 10455

Rapid City

Health Concepts, Rapid City, South Dakota, United States, 57702

Kingsport

Holston Medical Group, Kingsport, Tennessee, United States, 37660

Houston

Juno Research, LLC, Houston, Texas, United States, 77040

North Richland Hills

North Hills Medical Research Inc., North Richland Hills, Texas, United States, 76180

Norfolk

York Clinical Research LLC, Norfolk, Virginia, United States, 23504

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 18 to 80, body weight ≥ 50 kg
  • * Has uncontrolled hypertension while receiving between 2 and 5 antihypertensive medications prescribed for hypertension
  • * Has mean office seated systolic blood pressure \> 135 to ≤ 170 mmHg
  • * Has known history of secondary hypertension
  • * Has documented history of poor adherence to antihypertensive medication
  • * Has unstable/underlying known cardiovascular disease
  • * Has abnormal thyroid function with clinical significance

Ages Eligible for Study

18 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Kardigan, Inc.,

Study Record Dates

2027-12-20