RECRUITING

Pre-malignant States to Hematologic Malignancies in Firefighters

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of the study is to evaluate if firefighter exposure to hazardous compounds will increase the incidence of premalignant hematological states which subsequently increases the risk of the development of hematologic malignancies, and potentially other pathophysiological consequences.

Official Title

Pre-malignant States to Hematologic Malignancies in Firefighters

Quick Facts

Study Start:2025-06
Study Completion:2027-04
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06870760

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:40 Years to 49 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Written informed consent and HIPAA authorization for release of personal health information.
  2. 2. Age ≥ 40-49 years at the time of consent (self-reported)
  3. 3. Ability of the participant to understand and comply with study procedures for the entire length of the study
  4. 4. Currently employed by Charlotte Fire Department (CFD) with at least 5 years on-the -job experience (self-reported)
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Courtney Schepel
CONTACT
980-292-0817
courtney.schepel@atriumhealth.org

Principal Investigator

Larry Druhan, PhD
PRINCIPAL_INVESTIGATOR
Wake Forest University Health Sciences

Study Locations (Sites)

Levine Cancer Institute
Charlotte, North Carolina, 28204
United States

Collaborators and Investigators

Sponsor: Wake Forest University Health Sciences

  • Larry Druhan, PhD, PRINCIPAL_INVESTIGATOR, Wake Forest University Health Sciences

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-06
Study Completion Date2027-04

Study Record Updates

Study Start Date2025-06
Study Completion Date2027-04

Terms related to this study

Keywords Provided by Researchers

  • Firefighters
  • CHIP
  • MGUS

Additional Relevant MeSH Terms

  • Clonal Hematopoiesis of Indeterminate Potential
  • Monoclonal Gammopathy
  • Non Hodgkin Lymphoma
  • Leukemia
  • Multiple Myeloma
  • Plasma Cell Disorder