RECRUITING

Impact of Prehabilitation in Oncology Via Exercise- Esophageal (IMPROVE-Esophageal)

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this study is to determine the feasibility of a prehabilitation exercise and nutrition program (exercise and nutrition before a medical treatment) in adults with esophageal cancer before surgery (esophagectomy). The pre-surgery exercise and nutrition program will include resistance and aerobic training and nutrition supplementation during the weeks before surgery. We will also assess pre-surgical care needs in adults with esophageal cancer. Researchers will compare the exercise and nutrition intervention to usual care- which is standard medical care and post-surgery surveillance/follow-up to understand the impact of exercise and nutrition before surgery. We will follow-up with participants before surgery, and after surgery at 2 weeks, 6 weeks, and 4-months at appointments that coincide with clinical follow-ups. The main questions of this trials are: * Is exercise and nutrition supplementation before surgery for esophageal cancer feasible and acceptable to patients? * How does exercise and nutrition supplementation before surgery change physical function and psychosocial health? * What are important pre-surgical needs for adults with esophageal cancer?

Official Title

Impact of Prehabilitation in Oncology Via Exercise- Esophageal

Quick Facts

Study Start:2025-07-16
Study Completion:2026-10-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06872515

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Men and women, age ≥ 18 years old
  2. * Diagnosed with esophageal cancer
  3. * Identified as esophagectomy surgery candidates at Hillman Cancer Center or UPMC Shadyside
  4. * ≥ 2 weeks until scheduled esophagectomy
  5. * Currently completing, or completed Neoadjuvant chemotherapy
  6. * ECOG Performance Status Scale score of ≤ 2
  7. * Ability to provide written informed consent
  8. * Ability to understand, speak, and read English.
  1. * Evidence in the medical record of an absolute contraindication for exercise (e.g., Heart insufficiency \> NYHA III or uncertain arrhythmia; uncontrolled hypertension; reduced standing or walking ability)
  2. * Any other comorbidities or musculoskeletal complications that preclude participation in the exercise programs as deemed by the exercise interventionist
  3. * Receiving non-esophagectomy related chemotherapy and/or radiotherapy
  4. * Active infections, hemorrhages, and cytopenias that could place surgical patients at risk for further adverse events, deemed by the exercise interventionist, physician, and/or nurse

Contacts and Locations

Study Contact

Cara Battistella, MA
CONTACT
412-353-9102
battistellac@upmc.edu

Principal Investigator

Melanie Potiaumpai, PhD, MPH
PRINCIPAL_INVESTIGATOR
University of Pittsburgh

Study Locations (Sites)

UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, 15213
United States

Collaborators and Investigators

Sponsor: University of Pittsburgh

  • Melanie Potiaumpai, PhD, MPH, PRINCIPAL_INVESTIGATOR, University of Pittsburgh

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-07-16
Study Completion Date2026-10-01

Study Record Updates

Study Start Date2025-07-16
Study Completion Date2026-10-01

Terms related to this study

Keywords Provided by Researchers

  • Prehabilitation
  • Exercise
  • Esophageal cancer
  • Neoadjuvant chemotherapy
  • Pre-surgical exercise

Additional Relevant MeSH Terms

  • Esophageal Cancer
  • Esophageal Carcinoma