RECRUITING

Effect of Snacks on Aging

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to determine if daily consumption of 2 oz of pecans compared to 3.5 oz pretzel snacks for 12 weeks will 1) contribute to the body's ability to protect itself from oxidative damage (caused by oxygen radicals created by ultraviolet (UV) B light) by evaluating skin resistance to UV light irritation, skin fats/oils degradation and "rusting", and oxidative damage to the skin genes; and 2) explore the mechanisms of how snack consumption may affect aging by analyzing blood markers of aging as well as the microbes living in the gut (gut microbiome).

Official Title

Effect of Pecan Consumption on Aging

Quick Facts

Study Start:2025-05-19

Study Completion:2026-06-30

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT06879626

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:55 Years to 75 Years

Sexes Eligible for Study:FEMALE

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Female * Generally healthy * Aged 55-75 years * BMI 18.5-34.9 kg/m2 * Fitzpatrick Skin type II-IV * Consume a typical Western diet (low in polyphenols-rich foods and fiber) * Willing to maintain habitual dietary and exercise patterns for the study duration * Willing to maintain normal skin care products and pattern for the duration of the study * Willing to come to study visits without any makeup and skin products on * Subjects must read and sign the Institutional Review Board-approved written informed consent prior to the initiation of any study specific procedures or enrollment. A subject will be excluded for any condition that might compromise the ability to give truly informed consent.	* Vegetarian/vegan * Known nut allergy * Skin-related prescription medication, supplements or non-prescription cosmeceutical agents * Initiation of topical or oral prescription steroids and/or anti-inflammatory medications within 30 days prior to study enrollment * Excessive exposure to either natural or artificial sunlight * Screening laboratory values outside of the normal range that is considered clinically significant for study participation by the investigator * Documented chronic disease * Taking medications or supplements known to affect gut microbiota composition (antibiotics within the past 3 months, probiotics, fiber, etc.) * Taking exogenous hormones (e.g. hormone replacement therapy) * Recent weight fluctuations (\>10% in the last 6 months) * Smoker or living with a smoker * Use of \>20 g of alcohol per day * Unable or unwilling to comply with the study protocol (including unwillingness to avoid nuts for the whole duration of the study) * Unable to provide consent * Pregnancy and/or lactation

Inclusion Criteria

Exclusion Criteria

* Female
* Generally healthy
* Aged 55-75 years
* BMI 18.5-34.9 kg/m2
* Fitzpatrick Skin type II-IV
* Consume a typical Western diet (low in polyphenols-rich foods and fiber)
* Willing to maintain habitual dietary and exercise patterns for the study duration
* Willing to maintain normal skin care products and pattern for the duration of the study
* Willing to come to study visits without any makeup and skin products on
* Subjects must read and sign the Institutional Review Board-approved written informed consent prior to the initiation of any study specific procedures or enrollment. A subject will be excluded for any condition that might compromise the ability to give truly informed consent.

* Vegetarian/vegan
* Known nut allergy
* Skin-related prescription medication, supplements or non-prescription cosmeceutical agents
* Initiation of topical or oral prescription steroids and/or anti-inflammatory medications within 30 days prior to study enrollment
* Excessive exposure to either natural or artificial sunlight
* Screening laboratory values outside of the normal range that is considered clinically significant for study participation by the investigator
* Documented chronic disease
* Taking medications or supplements known to affect gut microbiota composition (antibiotics within the past 3 months, probiotics, fiber, etc.)
* Taking exogenous hormones (e.g. hormone replacement therapy)
* Recent weight fluctuations (\>10% in the last 6 months)
* Smoker or living with a smoker
* Use of \>20 g of alcohol per day
* Unable or unwilling to comply with the study protocol (including unwillingness to avoid nuts for the whole duration of the study)
* Unable to provide consent
* Pregnancy and/or lactation

Contacts and Locations

Study Contact

Tatiana Diacova, PhD, RD

CONTACT

310-206-8292

tdiacova@mednet.ucla.edu

Principal Investigator

Zhaoping Li, MD, PhD

PRINCIPAL_INVESTIGATOR

University of California, Los Angeles

Study Locations (Sites)

UCLA Center for Human Nutrition

Los Angeles, California, 90095

United States

Collaborators and Investigators

Sponsor: University of California, Los Angeles

Zhaoping Li, MD, PhD, PRINCIPAL_INVESTIGATOR, University of California, Los Angeles

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-05-19

Study Completion Date2026-06-30

Study Record Updates

Study Start Date2025-05-19

Study Completion Date2026-06-30

Terms related to this study

Additional Relevant MeSH Terms

Aging