Affect-based Impulsivity in Borderline Personality Disorder

Description

The purpose of this research study is to investigate how personality traits and neuroendocrine systems relate to decision-making patterns in individuals 18-45 years old. The main question it aims to answer is how neuroendocrine activity impacts decision-making. Participants will complete online behavioral tasks, a stress induction procedure, self-report surveys, and a cognitive assessment. During the session, psychophysiological measures will be collected, including electrocardiogram (ECG) and cardiac impedance (ICG) to monitor heart rate and blood flow, as well as electrodermal activity (EDA), blood drop samples, and saliva collection to assess nervous system activity.

Conditions

Borderline Personality Disorder (BPD), Healthy Controls Group - Age and Sex-matched

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Study Details

Study overview

The purpose of this research study is to investigate how personality traits and neuroendocrine systems relate to decision-making patterns in individuals 18-45 years old. The main question it aims to answer is how neuroendocrine activity impacts decision-making. Participants will complete online behavioral tasks, a stress induction procedure, self-report surveys, and a cognitive assessment. During the session, psychophysiological measures will be collected, including electrocardiogram (ECG) and cardiac impedance (ICG) to monitor heart rate and blood flow, as well as electrodermal activity (EDA), blood drop samples, and saliva collection to assess nervous system activity.

Affect-based Impulsivity in Borderline Personality Disorder: Developing a Neurocomputational Phenotype

Affect-based Impulsivity in Borderline Personality Disorder

Condition
Borderline Personality Disorder (BPD)
Intervention / Treatment

-

Contacts and Locations

Chapel Hill

University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States, 27514

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Score of 38 or higher on Personality Assessment Inventory-Borderline Scale (PAI-BOR)
  • * Participants in the BPD group will be primarily recruited from the two
  • 1. 3+ BPD symptoms, one of which must be affective instability, per clinical interview
  • 2. Participants must score at least 80 on the Reynolds Intellectual Screening Test (RIST).
  • * Score of 12 or lower on PAI-BOR
  • * Score below 50th percentile on World Health Organization Disability Assessment Schedule (WHODAS)
  • * Absence of any current or lifetime psychiatric disorder, including personality disorders as determined by diagnostic interviews (SIDP and SCID), if the participant had participated in the lab's other studies (IRB Nos. 20-1735 and 21-0602).
  • * Use of as needed antihypertensive agents within 12 hours prior to lab visit
  • * Inability to refrain from using as needed psychotropic medications for 12 hours prior to lab visit
  • * History of psychotic disorder, Bipolar I disorder, autism spectrum disorder, reactive attachment disorder, pervasive developmental disorder, motor disorder, head injury, mental retardation, neurological disorder, or current substance dependence
  • * Family history of Bipolar I disorder in a first degree relative.
  • * Participants are also excluded for any of the following: cardiac pacemaker, aneurysm clip, cochlear implants, pregnancy, shrapnel, history of metal fragments in eyes, neurostimulators, weight of 250 lbs. or more, or claustrophobia.

Ages Eligible for Study

18 Years to 45 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of North Carolina, Chapel Hill,

Michael Hallquist, PhD, PRINCIPAL_INVESTIGATOR, University of North Carolina, Chapel Hill

Study Record Dates

2026-04-01