RECRUITING

Sickle Cell, Pain and Mediterranean Diet

Conditions

Sickle Cell Sickle Cell Disease Sickle Cell Disease Without Crisis Mediterranean Diet sickle cell pain diet

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this study is to compare pain levels in individuals with Sickle Cell Disease while following the Mediterranean Diet to pain levels while following their usual diet.

Official Title

Exploring the Mediterranean Diet as A Promising Approach for Alleviating Chronic Pain in Sickle Cell Disease

Quick Facts

Study Start:2025-07-28

Study Completion:2026-12-01

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT06886477

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Sickle Cell Disease Diagnosis * Chronic non-vaso-occlusive pain experienced on average ≥ 3 days per week for \> 6 months (based on a response of "Most days," "Every day," or "Some days" and not "Never" to the question "In the past 6 months, how often have you had pain?") * Ability to speak, read, write, and understand English * A Mediterranean Eating Pattern for Americans (MEPA-III) score \<13, indicating that they do not follow a Mediterranean diet.	* Having taken systemic antimicrobials (to treat an infection in the previous 4 weeks) * History of colon cancer or inflammatory bowel disease (given potential untoward effects on the gut microbiome) * History of Clostridium difficile infection in the preceding 12 weeks; (4) unable to agree to maintain physical activity at the current level for the duration of the study * Currently following a Mediterranean diet, vegan diet, or dietary restrictions (e.g., religious, food intolerance/allergy) that preclude adoption of a Mediterranean diet * Lack of access to a space to safely store and reheat food items * Living in a facility that provides meals.

Inclusion Criteria

Exclusion Criteria

* Sickle Cell Disease Diagnosis
* Chronic non-vaso-occlusive pain experienced on average ≥ 3 days per week for \> 6 months (based on a response of "Most days," "Every day," or "Some days" and not "Never" to the question "In the past 6 months, how often have you had pain?")
* Ability to speak, read, write, and understand English
* A Mediterranean Eating Pattern for Americans (MEPA-III) score \<13, indicating that they do not follow a Mediterranean diet.

* Having taken systemic antimicrobials (to treat an infection in the previous 4 weeks)
* History of colon cancer or inflammatory bowel disease (given potential untoward effects on the gut microbiome)
* History of Clostridium difficile infection in the preceding 12 weeks; (4) unable to agree to maintain physical activity at the current level for the duration of the study
* Currently following a Mediterranean diet, vegan diet, or dietary restrictions (e.g., religious, food intolerance/allergy) that preclude adoption of a Mediterranean diet
* Lack of access to a space to safely store and reheat food items
* Living in a facility that provides meals.

Contacts and Locations

Study Contact

Lisa Tussing-Humphreys, PhD, MS, RD

CONTACT

312-355-5521

tussing@uic.edu

Study Locations (Sites)

University of Illinois Chicago

Chicago, Illinois, 60612

United States

Collaborators and Investigators

Sponsor: University of Illinois at Chicago

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-07-28

Study Completion Date2026-12-01

Study Record Updates

Study Start Date2025-07-28

Study Completion Date2026-12-01

Terms related to this study

Keywords Provided by Researchers

sickle cell
sickle cell disease
sickle cell pain
diet
Mediterranean diet

Additional Relevant MeSH Terms

Sickle Cell
Sickle Cell Disease
Sickle Cell Disease Without Crisis
Mediterranean Diet