RECRUITING

Radio- KO Radiotherapy for Knee Osteoarthritis Clinical Trial

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The primary aim of this study is to investigate whether low-dose radiotherapy is an effective treatment to reduce the pain of knee osteoarthritis. A secondary aim is to determine whether patients experience any more measurable side effects than those receiving sham treatments.

Official Title

The Randomized Clinical Trial of Low-Dose Radiotherapy for Knee Osteoarthritis

Quick Facts

Study Start:2025-06-04

Study Completion:2026-06-29

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT06887829

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:50 Years to 85 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* age 50-85 years * ICOAP pain scale A1 at least moderate intensity or B6 at least moderate intensity * diagnosed with primary knee OA ICD-10 codes M17.x * history of morning stiffness in knees that lasts less than 30 minutes * history of crepitus without a history of warmth, redness or sudden onset of swelling * physical exam findings of medial or lateral joint line tenderness on palpation that is in the same location as the knee pain for which their primary care provider has ordered an intraarticular steroid injection into the same knee. * absence of primary knee pain in the pes anserine or hamstring or gastrocnemius tendons * radiographic Kellgren-Lawrence grade 2-3 on 4-view knee x-rays taken within the last year * ability to complete surveys in English	* Kellgren-Lawrence grade 1 or 4 * pregnancy or women 54 years and younger with potential for pregnancy (if they or their partner have not had tubal ligation, hysterectomy, or vasectomy) * history of ipsilateral intraarticular knee surgery * use of injected corticosteroids within 3 months or hyaluronans within 6 months or within 1 month if there was no sustained improvement post-injection of either corticosteroid or hyaluronan. * history of trauma to this knee in the last year that clearly caused the pain now present * history of RA, gout, pseudogout, hemarthroses (eg, hemophilic arthropathy) or other inflammatory arthritis involving this knee * history of symptomatic hip OA * history of psychosis, personality disorder, uncontrolled affective disorder * history of fibromyalgia * malignancy requiring active treatment * current regular use of opiate analgesics, PRP, or acupuncture for the knees

Inclusion Criteria

Exclusion Criteria

* age 50-85 years
* ICOAP pain scale A1 at least moderate intensity or B6 at least moderate intensity
* diagnosed with primary knee OA ICD-10 codes M17.x
* history of morning stiffness in knees that lasts less than 30 minutes
* history of crepitus without a history of warmth, redness or sudden onset of swelling
* physical exam findings of medial or lateral joint line tenderness on palpation that is in the same location as the knee pain for which their primary care provider has ordered an intraarticular steroid injection into the same knee.
* absence of primary knee pain in the pes anserine or hamstring or gastrocnemius tendons
* radiographic Kellgren-Lawrence grade 2-3 on 4-view knee x-rays taken within the last year
* ability to complete surveys in English

* Kellgren-Lawrence grade 1 or 4
* pregnancy or women 54 years and younger with potential for pregnancy (if they or their partner have not had tubal ligation, hysterectomy, or vasectomy)
* history of ipsilateral intraarticular knee surgery
* use of injected corticosteroids within 3 months or hyaluronans within 6 months or within 1 month if there was no sustained improvement post-injection of either corticosteroid or hyaluronan.
* history of trauma to this knee in the last year that clearly caused the pain now present
* history of RA, gout, pseudogout, hemarthroses (eg, hemophilic arthropathy) or other inflammatory arthritis involving this knee
* history of symptomatic hip OA
* history of psychosis, personality disorder, uncontrolled affective disorder
* history of fibromyalgia
* malignancy requiring active treatment
* current regular use of opiate analgesics, PRP, or acupuncture for the knees

Contacts and Locations

Study Contact

Family Medicine Research Study Coordinators

CONTACT

507-422-6823

RSTFMSC@mayo.edu

Principal Investigator

Stephen P. Merry, M.D.

PRINCIPAL_INVESTIGATOR

Mayo Clinic

Paul D. Brown, M.D.

PRINCIPAL_INVESTIGATOR

Mayo Clinic

Study Locations (Sites)

Mayo Clinic

Rochester, Minnesota, 55905

United States

Collaborators and Investigators

Sponsor: Mayo Clinic

Stephen P. Merry, M.D., PRINCIPAL_INVESTIGATOR, Mayo Clinic
Paul D. Brown, M.D., PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-06-04

Study Completion Date2026-06-29

Study Record Updates

Study Start Date2025-06-04

Study Completion Date2026-06-29

Terms related to this study

Additional Relevant MeSH Terms

Osteoarthritis, Knee