Optimization of Chrononutrition to Reduce the Risk of Disease in Shift Workers

Eligibility Criteria

• * Age: 18-70 years
• * BMI ≥ 25 kg/m2
• * Own a smartphone (Apple iOS or Android OS)
• * Baseline eating window ≥ 14 h/day
• * Night shift nurses and nursing assistants who are working a 12-hour night shift at least 3 days/week.
• * Have been doing night shift work for at least 3 months.
• * Patients on cardiovascular medications (HMG CoA reductase inhibitors (statins), metformin, lipid-modifying drugs (including over-the-counter drugs such as red yeast rice and fish oil), anti-hypertensive, drugs), are allowed
• * If patients have Type 2 Diabetes, they will be included in the study if A1c is less than 9 and they are not on insulin.
• * Insufficient dietary logging on the mCC app is defined as less than 7 of 14 days of baseline of dietary logging with a minimum of 2 items a day, at least 5 hours apart.
• * Type 1 Diabetes or Insulin-dependent Type 2 Diabetes.
• * Use of sulfonylurea or insulin within the last 3 months (due to unknown safety with TRE)
• * Use of medications that are known to cause weight loss such as SGLT2 inhibitors and GLP1 receptor agonists)
• * BMI \> 42 kg/m2
• * Change in medications that could impact study outcomes within the past 3 months
• * Change in weight of \>4kg in the past 3 months
• * Women who are pregnant, breastfeeding, or are trying to become pregnant during the study period. If a participant becomes pregnant during the study, they will be excluded from continuing the study.
• * Systolic BP greater than 160 mmHg and/or diastolic BP greater than 110 mmHg at rest
• * Fasting LDL cholesterol greater than 250 mg/dL
• * Fasting triglycerides greater than 500g/dL
• * Active tobacco abuse or illicit drug use or history of treatment for alcohol abuse in the past 5 years.
• * Frequent (more than 4) travel involving a time zone change of more than 3 hours over the 1-year study period
• * Prolonged leave from work (a continuous month or longer) during the study
• * Active treatment for inflammatory and/or rheumatologic disease
• * History of a major adverse cardiovascular event within the past year (acute coronary syndrome, percutaneous coronary intervention, coronary artery bypass graft surgery, hospitalization for congestive heart failure, stroke/transient ischemic attack)
• * Uncontrolled arrhythmia (i.e. rate-controlled atrial fibrillation/atrial flutter are acceptable)
• * History of thyroid disease requiring dose titration of thyroid replacement medication(s) within the past 3 months (hypothyroidism on a stable dose of thyroid replacement therapy is allowed).
• * History of adrenal disease in the past 5 years
• * History of malignancy undergoing active treatment, except non-melanoma skin cancer, in the past 5 years
• * History of an eating disorder in the past 5 years
• * History of cirrhosis in the past 5 years
• * History of stage 4 or 5 chronic kidney disease or dialysis in the past 5 years
• * History of HIV/AIDs
• * Currently enrolled in weight-loss or weight-management program
• * Any history of surgical intervention for weight management
• * Uncontrolled psychiatric disorder including prior hospitalization