EEG-based Personalized Transcranial Magnetic Stimulation (eTMS) to Treat Post-Traumatic Stress Disorder

Description

This is a randomized, sham controlled study of the Electroencephalogram (EEG) based Transcranial Magnetic Stimulation (eTMS) treatment for Post-Traumatic Stress Disorder (PTSD). The recruitment goal is 110 participants who are United States Military veterans or first responders (e.g., firefighters, police, paramedics, etc.). The Study includes an EEG recording in order to determine the optimal treatment parameters for the eTMS system, followed by 15 in-office visits that take place over 21-28 total days. Two eTMS treatment sessions are administered during each office visit.

Conditions

Stress Disorder, Post Traumatic

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Study Overview

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Study Details

Study overview

This is a randomized, sham controlled study of the Electroencephalogram (EEG) based Transcranial Magnetic Stimulation (eTMS) treatment for Post-Traumatic Stress Disorder (PTSD). The recruitment goal is 110 participants who are United States Military veterans or first responders (e.g., firefighters, police, paramedics, etc.). The Study includes an EEG recording in order to determine the optimal treatment parameters for the eTMS system, followed by 15 in-office visits that take place over 21-28 total days. Two eTMS treatment sessions are administered during each office visit.

A Randomized Controlled Trial of Electroencephalogram (EEG) Personalized Transcranial Magnetic Stimulation (eTMS) for Post-Traumatic Stress Disorder

EEG-based Personalized Transcranial Magnetic Stimulation (eTMS) to Treat Post-Traumatic Stress Disorder

Condition
Stress Disorder, Post Traumatic
Intervention / Treatment

-

Contacts and Locations

Dayton

Wright State University, Dayton, Ohio, United States, 45435

Pickerington

D2 Human Performance Center, Pickerington, Ohio, United States, 45435

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Willing and able to consent to participate in the study via signed Informed Consent
  • * Age 22 - 65 years
  • * Diagnosis of PTSD according to DSM-5 criteria via the Clinician-Administered PTSD Scale (CAPS).
  • * Onset of symptoms meeting the DSM-5 criteria for PTSD symptoms persisting for a minimum of 6 months prior to the Screening Visit
  • * Veterans Administration PCL-5 cut point score of 31 or above
  • * Positive identification as either a Veteran, or First Responder (e.g., emergency medical service provider, firefighter, or any other emergency response personnel)
  • * Uncontrolled medical, psychological or neurological condition
  • * Pregnant, or female unwilling to use effective birth control during the course of the trial
  • * Metal objects in the head
  • * Past exposure to metal fragments, permanent piercings, and/or other possible metal sources in the head and neck
  • * Current participation in any interventional research protocol
  • * History of any type of Electroconvulsive Therapy (ECT) or repetitive Transcranial Magnetic Stimulation (rTMS)
  • * History of stroke or intracranial lesion or increased intracranial pressure
  • * History of epilepsy of seizure
  • * Family history of epilepsy or seizure in 1st degree relative
  • * An elevated risk of suicide or violence to others

Ages Eligible for Study

22 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Wave Neuroscience,

Bill Phillips, PhD, PRINCIPAL_INVESTIGATOR, Wave Neuroscience, Inc.

Study Record Dates

2026-01-31