Pleuroscopy First Versus Thoracentesis First in Patients with Suspected Malignant Pleural Effusions

Description

This is a randomized control trial of patients with suspected malignant pleural effusions to compare whether patients who have a thoracentesis or pleuroscopy (pleural biopsy) obtain an adequate biopsy, achieve a diagnosis, and begin cancer-directed therapy faster.

Conditions

Pleural Effusion, Cancer

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Study Overview

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Study Details

Study overview

This is a randomized control trial of patients with suspected malignant pleural effusions to compare whether patients who have a thoracentesis or pleuroscopy (pleural biopsy) obtain an adequate biopsy, achieve a diagnosis, and begin cancer-directed therapy faster.

Pleuroscopy First Versus Thoracentesis First in Patients with Suspected Malignant Pleural Effusions

Pleuroscopy First Versus Thoracentesis First in Patients with Suspected Malignant Pleural Effusions

Condition
Pleural Effusion
Intervention / Treatment

-

Contacts and Locations

New York

Mount Sinai West, New York, New York, United States, 10019

New York

Mount Sinai Hospital, New York, New York, United States, 10029

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Referral for diagnostic pleural procedure.
  • * Age ≥ 18 years.
  • * Suspected malignant pleural effusion (Suggestive radiologic appearance (based on computed tomography or positron emission tomography) OR suspected cancer with associated effusion.)
  • * Inability to provide informed consent.
  • * Needs emergent drainage.
  • * Pleural effusion is known to be malignant.
  • * Suspected transudative, infectious or inflammatory effusion etiology.
  • * Having prior inconclusive/non-diagnostic thoracentesis or pleuroscopy.
  • * Patient is deemed by the clinical team to be more appropriate for VATS biopsy.
  • * Terminally ill patients in whom a diagnosis will not change management, or who is unlikely to be a candidate for oncological treatment due to significant comorbidities.
  • * Pregnancy

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Icahn School of Medicine at Mount Sinai,

Udit Chaddha, MBBS, PRINCIPAL_INVESTIGATOR, MOUNT SINAI HOSPITAL

Study Record Dates

2026-09-17