Psilocybin-Assisted Therapy for Intergenerational Trauma

Eligibility Criteria

• * Age at least 18 years old at time of signing the informed consent
• * Biological child of at least one parent who directly survived/escaped a genocide
• * Meets diagnostic criteria for a depressive or anxiety disorder
• * Capable of providing informed consent and complying with study procedures
• * Currently using or agreeing to use adequate contraceptive methods.
• * Fluent in speaking and reading English
• * Able to swallow pills
• * Agrees to have study visits recorded with audio and video
• * Able to provide a contact person who can be reached by investigators in the event of the participant becoming unwell or unreachable
• * Agrees to inform the investigators within 48 hours of any medical conditions and procedures
• * Agrees to release of outside medical and psychiatric records
• * Must not participate in any other interventional clinical trials for the duration of the study.
• * Must commit to medication dosing, therapy, and all study procedures.
• * Not able to give adequate informed consent.
• * Was directly exposed to or survived a genocide.
• * Has a history of any medical condition, or any significant clinical finding on screening tests, that could make receiving psilocybin harmful.
• * Has acute, severe or unstable medical illness.
• * Has a history of stroke or Transient Ischemic Attack (TIA).
• * Has a history of psychiatric hospitalization within the last 6 months.
• * Current serious suicide risk.
• * Unable or unwilling to safely taper off prohibited psychiatric medications.
• * Abusing alcohol or other substances.
• * Has used psychedelics within 3 months of enrollment.
• * Are pregnant or nursing or able to become pregnant and are not practicing an effective means of contraception.