Assessing Chest Pain Using Point-of-Care High-Sensitivity Troponin I in the Emergency Department

Description

The goal of this proposal is to improve the quality and value of care for patients with acute chest pain by investigating the potential impact of point-of-care (POC) high sensitivity cardiac troponin (hs-cTn) testing in the Emergency Department (ED) and exploring how best to integrate POC hs-cTnl into ED risk stratification workflows. The study hypothesizes that the Abbott i-STAT POC hs-cTnI assay will decrease time-to-result (TTR) and ED length of stay (LOS), while increasing ED revenue for patients with acute chest pain compared to a strategy of central laboratory hs-cTnI testing.

Conditions

ACS (Acute Coronary Syndrome)

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Study Overview

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Study Details

Study overview

The goal of this proposal is to improve the quality and value of care for patients with acute chest pain by investigating the potential impact of point-of-care (POC) high sensitivity cardiac troponin (hs-cTn) testing in the Emergency Department (ED) and exploring how best to integrate POC hs-cTnl into ED risk stratification workflows. The study hypothesizes that the Abbott i-STAT POC hs-cTnI assay will decrease time-to-result (TTR) and ED length of stay (LOS), while increasing ED revenue for patients with acute chest pain compared to a strategy of central laboratory hs-cTnI testing.

Assessing Chest Pain Using Point-of-Care High-Sensitivity Troponin I in the Emergency Department

Assessing Chest Pain Using Point-of-Care High-Sensitivity Troponin I in the Emergency Department

Condition
ACS (Acute Coronary Syndrome)
Intervention / Treatment

-

Contacts and Locations

Charlotte

Carolinas Medical Center, Charlotte, North Carolina, United States, 28203

High Point

High Point Medical Center, High Point, North Carolina, United States, 27262

Winston-Salem

Wake Forest School of Medicine, Winston-Salem, North Carolina, United States, 27517

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age greater than or equal to18 years
  • * Symptoms suggestive of acute coronary syndrome:
  • * Acute chest, epigastric, neck, jaw or arm pain or discomfort or pressure without apparent non-cardiac source
  • * Shortness of breath, nausea, vomiting, fatigue/malaise, or
  • * Other equivalent discomfort suggestive of an myocardial infarction (MI)
  • * Electrocardiogram (ECG) ordered as part of standard of care
  • * At least one troponin collected as standard of care
  • * Study specific blood sample collected within ± 5 minutes of clinical draw
  • * ST-segment elevation myocardial infarction (STEMI) Activation
  • * Unstable vitals signs: symptomatic hypotension at the time of enrollment (systolic \< 90 mm Hg), tachycardia (HR\>120), bradycardia (HR\<40), and hypoxemia (\<90% pulse-oximetry on room air or normal home oxygen flow rate)
  • * Central laboratory hs-cTn testing resulted or in process (\>5 minutes) prior to study accrual
  • * Prior enrollment
  • * Terminal diagnosis with life expectancy less than 6 months

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Wake Forest University Health Sciences,

Simon Mahler, MD, MS, PRINCIPAL_INVESTIGATOR, Wake Forest University Health Sciences

Study Record Dates

2026-02-01