Ultralow Dose PET Imaging for PSMA Expression

Description

The goal of this clinical trial is to evaluate an investigational ultralow dose PET imaging technique for prostate cancer detection and monitoring. The main question it aims to answer is: Can the investigators optimize the timing, scan duration, and image reconstruction to reduce the radiation dose 10-100 fold of the current clinical standard? Participants will be injected with a radioactive tracer called 18F-DCFPyL and be imaged on a new type of high sensitivity PET scanner for up to 3 hours

Conditions

Healthy Volunteer, Prostate CA

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Study Overview

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Study Details

Study overview

The goal of this clinical trial is to evaluate an investigational ultralow dose PET imaging technique for prostate cancer detection and monitoring. The main question it aims to answer is: Can the investigators optimize the timing, scan duration, and image reconstruction to reduce the radiation dose 10-100 fold of the current clinical standard? Participants will be injected with a radioactive tracer called 18F-DCFPyL and be imaged on a new type of high sensitivity PET scanner for up to 3 hours

Evaluation of Ultralow Dose PET Imaging for Detecting PSMA Expression

Ultralow Dose PET Imaging for PSMA Expression

Condition
Healthy Volunteer
Intervention / Treatment

-

Contacts and Locations

Englewood

Nuclear Imaging Institute, Englewood, New Jersey, United States, 07631

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Age ≥18 years.
  • 2. Ability to provide informed consent and comply with study procedures.
  • 3. For female participants:
  • * Must not be pregnant or breastfeeding.
  • * Negative pregnancy test required for women of childbearing potential.
  • 1. Participants who have exceeded NRC regulation for annual radiation exposure from prior research-related scans, including this study (50 mSv total).
  • 2. More than four prior enrollments in this study.
  • 3. Participants with severe claustrophobia, chronic pain, or musculoskeletal conditions that prevent completion of the PET scan
  • 4. Medication \& Prior Treatment Exclusions
  • 5. Pregnant or breastfeeding individuals (negative pregnancy test required)
  • 6. Inability to provide informed consent
  • 7. Any condition that, in the investigator's judgment, may compromise participant safety or study integrity.

Ages Eligible for Study

18 Years to 120 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Akiva Mintz,

Study Record Dates

2030-06-30