Preoperative 5-Day Radiotherapy for Soft Tissue Sarcoma

Description

The purpose of this research study is to preserve healthy tissue around the cancer on the arm(s) and/or leg(s) using Hypofractionated radiotherapy, while treating the cancer and preventing it from spreading to other areas of the body.

Conditions

Soft Tissue Sarcoma

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Study Overview

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Study Details

Study overview

The purpose of this research study is to preserve healthy tissue around the cancer on the arm(s) and/or leg(s) using Hypofractionated radiotherapy, while treating the cancer and preventing it from spreading to other areas of the body.

Preoperative 5-Day Radiotherapy for Soft Tissue Sarcoma: A Single Institution Phase II Trial

Preoperative 5-Day Radiotherapy for Soft Tissue Sarcoma

Condition
Soft Tissue Sarcoma
Intervention / Treatment

-

Contacts and Locations

Charleston

Medical University of South Carolina, Charleston, South Carolina, United States, 29401

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Willingness and provision of informed consent via signed and dated copy.
  • * Histologically confirmed STS of extremity or trunk.
  • * Male or female, aged greater than or equal to 18 years old
  • * ECOG performance status 0-3
  • * Meets screening criteria for receipt of radiotherapy.
  • * Deemed eligible for wide local excision.
  • * Patient and/or physician identified possible barriers to receiving a 5-week course of conventionally fractionated preoperative radiotherapy. Potential barriers include but are not limited to concern for local progression that could precluded or complicate limb sparing surgery, concern for distant progression that could result in patient being non-operative, financial and/or physical burden of travel for daily treatments, financial burden of time away from work or caregiving.
  • * Distant metastatic disease
  • * Prior radiation therapy in the proposed treatment area
  • * Simultaneous treatment of another malignancy
  • * Women who are pregnant or plan to become pregnant during the period of radiation therapy
  • * Planned concurrent administration of chemotherapy and radiation therapy

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Medical University of South Carolina,

Jennifer Harper, MD, PRINCIPAL_INVESTIGATOR, Medical University of South Carolina

Study Record Dates

2027-03-31