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Yeast Mannans and Stool Frequency

Description

Findings from an open-label pilot study of 20 adults suggested that supplementation with 15 g/day of yeast mannans was highly tolerable and demonstrated specific modulation of the microbiota and increased stool frequency in a subset of subjects reporting ≤1 stool per day at baseline. The primary aim of this randomized, double-blind, controlled trial is to determine if yeast mannan supplementation at 12 g/day will increase stool frequency in generally healthy adults reporting ≤1 stool per day. Secondary aims will determine the effect of yeast mannans on intestinal transit time, gastrointestinal symptoms, fecal microbiota composition, and urinary and fecal metabolomics.

Conditions

Defecation Frequency
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Related Conditions:

Defecation Frequency

Study Overview

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Study Details

Study overview

Findings from an open-label pilot study of 20 adults suggested that supplementation with 15 g/day of yeast mannans was highly tolerable and demonstrated specific modulation of the microbiota and increased stool frequency in a subset of subjects reporting ≤1 stool per day at baseline. The primary aim of this randomized, double-blind, controlled trial is to determine if yeast mannan supplementation at 12 g/day will increase stool frequency in generally healthy adults reporting ≤1 stool per day. Secondary aims will determine the effect of yeast mannans on intestinal transit time, gastrointestinal symptoms, fecal microbiota composition, and urinary and fecal metabolomics.

Efficacy of Yeast Mannan Supplementation on Increasing Stool Frequency in Generally Healthy Adults: A Randomized Controlled Trial

Yeast Mannans and Stool Frequency

Condition
Defecation Frequency
Intervention / Treatment

-

Contacts and Locations

Gainesville

Department of Food Science and Human Nutrition, Gainesville, Florida, United States, 32611

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Adults who report a stool frequency of ≤ 1 per day.
  • * Able to provide written informed consent in English.
  • * Willingness to consume 1 supplement (12 g of yeast mannans or control) daily for 28 days.
  • * Willingness to maintain their usual diet and physical activity patterns throughout the study and refrain from the consumption of any yeast-based foods (e.g. Marmite or Vegemite) or yeast extract supplements.
  • * Willing to comply with study procedures, including stool and urine colle
  • * Stool frequency of \< 3 per week
  • * Yeast allergy
  • * Vegan dietary pattern
  • * Self-reported kidney disease
  • * Elite athletes or long-distance runners
  • * Use of antibiotic drugs within 1 month of screening
  • * Current use of laxatives or antidiarrheal medications
  • * Use of other investigational products within 3 months of the screening
  • * Previously or currently being treated for intestinal diseases or conditions, including irritable bowel disease (i.e., IBS-D or IBS-mixed), Crohn's disease, ulcerative colitis, celiac disease, or gastrointestinal cancer.
  • * Previous gastrointestinal surgery (e.g., gastric bypass, fundoplication, bowel resection).
  • * Current cancer treatment.
  • * Currently pregnant.

Ages Eligible for Study

18 Years to 90 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Florida,

Study Record Dates

2026-06-30