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Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease

Description

Locomotor adaptation will be studied using an established split-belt treadmill paradigm, consisting of baseline (1:1 speed ratio), split-belt adaptation (2:1) and post-adaptation (1:1) walking. Split-belt walking will be performed under DBS ON and DBS OFF conditions, while off-medication.

Conditions

Parkinson Disease
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Related Conditions:

Parkinson Disease

Study Overview

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Study Details

Study overview

Locomotor adaptation will be studied using an established split-belt treadmill paradigm, consisting of baseline (1:1 speed ratio), split-belt adaptation (2:1) and post-adaptation (1:1) walking. Split-belt walking will be performed under DBS ON and DBS OFF conditions, while off-medication.

Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease

Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease

Condition
Parkinson Disease
Intervention / Treatment

-

Contacts and Locations

Gainesville

University of Florida, Gainesville, Florida, United States, 32611

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * consensus diagnosis of idiopathic PD by fellowship trained movement disorders neurologists at the Normal Fixel Institute of Neurological Diseases;
  • * chronically stable DBS, defined as having had DBS for at least 6 months in duration with optimized DBS settings;
  • * Age between 18 - 80 years old per the FDA data sheet for PD DBS;
  • * no dementia according to the clinical diagnostic criteria for PD dementia;
  • * ambulatory without the use of walking aids, or another person's assistance.
  • * other previous neurological surgery;
  • * suspicion of other neurologic diagnoses such as atypical parkinsonism, or Alzheimer's disease.

Ages Eligible for Study

18 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Florida,

Study Record Dates

2028-12-31