RECRUITING

Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Locomotor adaptation will be studied using an established split-belt treadmill paradigm, consisting of baseline (1:1 speed ratio), split-belt adaptation (2:1) and post-adaptation (1:1) walking. Split-belt walking will be performed under DBS ON and DBS OFF conditions, while off-medication.

Official Title

Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease

Quick Facts

Study Start:2025-08-01
Study Completion:2028-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06911229

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 80 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * consensus diagnosis of idiopathic PD by fellowship trained movement disorders neurologists at the Normal Fixel Institute of Neurological Diseases;
  2. * chronically stable DBS, defined as having had DBS for at least 6 months in duration with optimized DBS settings;
  3. * Age between 18 - 80 years old per the FDA data sheet for PD DBS;
  4. * no dementia according to the clinical diagnostic criteria for PD dementia;
  5. * ambulatory without the use of walking aids, or another person's assistance.
  1. * other previous neurological surgery;
  2. * suspicion of other neurologic diagnoses such as atypical parkinsonism, or Alzheimer's disease.

Contacts and Locations

Study Contact

Julia Choi, Ph.D.
CONTACT
3522941720
juliachoi@ufl.edu

Study Locations (Sites)

University of Florida
Gainesville, Florida, 32611
United States

Collaborators and Investigators

Sponsor: University of Florida

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-08-01
Study Completion Date2028-12-31

Study Record Updates

Study Start Date2025-08-01
Study Completion Date2028-12-31

Terms related to this study

Keywords Provided by Researchers

  • Freezing of gait
  • deep brain stimulation

Additional Relevant MeSH Terms

  • Parkinson Disease