A Study to Evaluate the Drug-Drug Interaction of EDP-323 With Midazolam, Caffeine, and Rosuvastatin in Healthy Participants

Eligibility Criteria

• * An informed consent document signed and dated by the subject
• * Healthy male and female subjects of any ethnic origin between the ages of 18 and 65 years, inclusive
• * Screening body weight \>50 kg and body mass index (BMI) of 18 to 32 kg/m2
• * Female subjects of childbearing potential must agree to use two effective methods of contraception from the date of Screening until 30 days after the last dose of EDP-323. A male participant who has not had a vasectomy and is sexually active with a woman of childbearing potential must agree to use effective contraception from the date of Screening to 90 days after his last dose of study drug.
• * Clinically relevant evidence or history of illness or disease
• * Pregnant or nursing females
• * History of febrile illness within 7 days prior to the first dose of study drug or subjects with evidence of active infection
• * Any condition possibly affecting drug absorption (e.g., gastrectomy, cholecystectomy)
• * Positive for HIV or hepatitis
• * Positive urine drug screen
• * Current tobacco smokers or use of tobacco within 3 months prior to Screening.
• * Received any vaccine, an investigational agent, or biological product within 28 days or 5 times the t½ of receipt of study drug, whichever is longer.
• * Drug sensitivity to midazolam, caffeine, rosuvastatin