RECRUITING

Use of a Generative AI (Gen-AI) Chatbot for Anxiety and Depression Among Persons With Cannabis Use

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical trial is to learn if Therabot-CALM (Cannabis, Anxiety, Low Mood) has acceptability among users and could work to improve the symptoms of persons with cannabis use disorder and anxiety and/or depression. The main question it aims to answer is: What is the usability, feasibility, and acceptability of Therabot-CALM in persons with Cannabis Use Disorder and Anxiety and/or Depression? Participants will * Take a screening questionnaire * Participate in two virtual 1-hour interviews to provide feedback on app design and suggest features. * Engage with Therabot-CALM in a 4-week clinical trial and provide feedback on their app experience in a third virtual interview

Official Title

A Phase I Single-Arm Trial to Test the Use of a Generative AI (Gen-AI) Chatbot for Anxiety and Depression Among Persons With Cannabis Use Disorder (CUD)

Quick Facts

Study Start:2025-04
Study Completion:2025-11
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06920238

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Is 18 years or older.
  2. * Meet criteria for current CUD (CUDIT-R\>=12) and MDD (PHQ-9\>=10), and/or GAD (GAD-7\>=10).
  3. * Have reliable access to the internet and a compatible device for Therabot-CALM.
  4. * Have willingness and capacity to provide informed consent and commit to participating in all assessments and interventions during the study.
  5. * Attend the first interview.
  1. * Moderate to High risk of STBs as determined by the C-SSRS or baseline questionnaires.
  2. * Current psychosis (as determined by brief psychosis screen).
  3. * Current participation in another digital mental health intervention.

Contacts and Locations

Study Contact

Michael V Heinz, MD
CONTACT
(603) 277-9110
michael.v.heinz@hitchcock.org
Amanda C Collins, Ph.D.
CONTACT
Amanda.C.Collins@dartmouth.edu

Principal Investigator

Nicholas C Jacobson, Ph.D.
PRINCIPAL_INVESTIGATOR
Center for Technology and Behavioral Health, Geisel School of Medicine, Dartmouth College

Study Locations (Sites)

46 Centerra Parkway, Suite 300, Office #333S
Lebanon, New Hampshire, 03766
United States

Collaborators and Investigators

Sponsor: Trustees of Dartmouth College

  • Nicholas C Jacobson, Ph.D., PRINCIPAL_INVESTIGATOR, Center for Technology and Behavioral Health, Geisel School of Medicine, Dartmouth College

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-04
Study Completion Date2025-11

Study Record Updates

Study Start Date2025-04
Study Completion Date2025-11

Terms related to this study

Keywords Provided by Researchers

  • Artifical Intelligence
  • Generative AI
  • Generative Artificial Intelligence
  • Therabot
  • Therabot-CALM
  • Cannabis Use Disorder
  • Anxiety
  • Depression
  • Chatbot
  • Cannabis Use
  • Drug Abuse
  • Drug Use
  • Drug Use Disorder
  • Interview
  • Screening
  • Application
  • REDCap
  • post-intervention measures
  • System Usability Scale
  • Treatment Acceptability and Adherence Scale
  • Cannabis Use Disorders Identification Test - Revised
  • Cannabis Use Disorders Identification Test
  • Quantity of Cannabis Use Inventory
  • Patient Health Questionnaire for depression
  • generalized anxiety disorder screener
  • DSM-5
  • Zoom

Additional Relevant MeSH Terms

  • Cannabis Use Disorder
  • Anxiety
  • Depression, Anxiety
  • Depression - Major Depressive Disorder