Use of a Generative AI (Gen-AI) Chatbot for Anxiety and Depression Among Persons With Cannabis Use

Description

The goal of this clinical trial is to learn if Therabot-CALM (Cannabis, Anxiety, Low Mood) has acceptability among users and could work to improve the symptoms of persons with cannabis use disorder and anxiety and/or depression. The main question it aims to answer is: What is the usability, feasibility, and acceptability of Therabot-CALM in persons with Cannabis Use Disorder and Anxiety and/or Depression? Participants will * Take a screening questionnaire * Participate in two virtual 1-hour interviews to provide feedback on app design and suggest features. * Engage with Therabot-CALM in a 4-week clinical trial and provide feedback on their app experience in a third virtual interview

Conditions

Cannabis Use Disorder, Anxiety, Depression, Anxiety, Depression - Major Depressive Disorder

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Study Overview

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Study Details

Study overview

The goal of this clinical trial is to learn if Therabot-CALM (Cannabis, Anxiety, Low Mood) has acceptability among users and could work to improve the symptoms of persons with cannabis use disorder and anxiety and/or depression. The main question it aims to answer is: What is the usability, feasibility, and acceptability of Therabot-CALM in persons with Cannabis Use Disorder and Anxiety and/or Depression? Participants will * Take a screening questionnaire * Participate in two virtual 1-hour interviews to provide feedback on app design and suggest features. * Engage with Therabot-CALM in a 4-week clinical trial and provide feedback on their app experience in a third virtual interview

A Phase I Single-Arm Trial to Test the Use of a Generative AI (Gen-AI) Chatbot for Anxiety and Depression Among Persons With Cannabis Use Disorder (CUD)

Use of a Generative AI (Gen-AI) Chatbot for Anxiety and Depression Among Persons With Cannabis Use

Condition
Cannabis Use Disorder
Intervention / Treatment

-

Contacts and Locations

Lebanon

46 Centerra Parkway, Suite 300, Office #333S, Lebanon, New Hampshire, United States, 03766

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Is 18 years or older.
  • * Meet criteria for current CUD (CUDIT-R\>=12) and MDD (PHQ-9\>=10), and/or GAD (GAD-7\>=10).
  • * Have reliable access to the internet and a compatible device for Therabot-CALM.
  • * Have willingness and capacity to provide informed consent and commit to participating in all assessments and interventions during the study.
  • * Attend the first interview.
  • * Moderate to High risk of STBs as determined by the C-SSRS or baseline questionnaires.
  • * Current psychosis (as determined by brief psychosis screen).
  • * Current participation in another digital mental health intervention.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Trustees of Dartmouth College,

Nicholas C Jacobson, Ph.D., PRINCIPAL_INVESTIGATOR, Center for Technology and Behavioral Health, Geisel School of Medicine, Dartmouth College

Study Record Dates

2025-11