RECRUITING

Team Science (The Liver Health Study)

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Liver damage from alcohol intake and weight-related behaviors is preventable and treatable only through lifestyle changes. This mixed-methods randomized controlled trial compares standard and enhanced approaches to screening, brief intervention, and referral to treatment/prevention (SBIRT/P) to identify and intervene for metabolism- and alcohol-associated liver disease (MetALD). Our multidisciplinary team aims to show that integrating results of noninvasive liver screening with Fibroscan®, a painless ultrasound that measures stiffness and fat in the liver, can optimize our brief intervention. The study population is adults age 21+ who speak Spanish or English from underresourced communities with alcohol- and weight-related risks for MetALD.

Official Title

Team Science to Identify & Intervene on Metabolism- & Alcohol-Associated Liver Disease

Quick Facts

Study Start:2025-04
Study Completion:2025-07
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06924281

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:21 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Be at least 21 years of age.
  2. * Exceed alcohol intake screening guidelines for MetALD.
  3. * Have a Body Mass Index (BMI) \>=25 kg/m2.
  4. * Be able to speak and read English or Spanish to provide written informed consent and understand written and oral instructions in English or Spanish.
  1. * Pre-existing liver disease or hepatocellular carcinoma or prior liver transplant.
  2. * Pre-existing medical conditions that, in the opinion of the investigative team, would interfere with research participation (e.g., loss of kidney function, uncontrolled infections, multiorgan failure, uncontrolled upper gastrointestinal bleeding, other active malignancies except skin cancer).
  3. * Pre-existing mental health conditions that, in the opinion of the investigative team, would interfere with the ability to provide informed consent and understand written and oral instructions (e.g., hepatic encephalopathy, psychotic disorder diagnosis or symptoms).
  4. * Current pregnancy.
  5. * Be anyone who, based on self-reported withdrawal symptoms and the opinion of the investigative team, could not currently safely be withdrawn from alcohol without medical detoxification.
  6. * Currently receiving formalized psychosocial treatment for an alcohol use or drug problem and/or newly taking medications for an alcohol use or drug problem.
  7. * Currently receiving formalized behavioral weight management treatment and/or newly taking weight loss medications.

Contacts and Locations

Study Contact

Primary Researcher
CONTACT
401-863-6623
liverhealth@brown.edu

Study Locations (Sites)

Clinica Esperanza Hope Clinic
Providence, Rhode Island, 02909
United States

Collaborators and Investigators

Sponsor: Brown University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-04
Study Completion Date2025-07

Study Record Updates

Study Start Date2025-04
Study Completion Date2025-07

Terms related to this study

Keywords Provided by Researchers

  • Metabolism and alcohol-associated liver disease
  • Motivational interviewing
  • Personalized feedback

Additional Relevant MeSH Terms

  • Steatotic Liver Disease of Mixed Origin (MetALD)